histiocytic lesion

(redirected from Histiocytic proliferations)

histiocytic lesion

An aggregate of histiocytes, which may be benign, indeterminant, or malignant in proliferative potential; to reduce confusion, it has been suggested that histiocytoses be subdivided into different categories
Histiocytic lesions-Behavior classification  
Benign
Familial histiocytosis with eosinophilia A chronic disease of infants with recurring bacterial infections, diarrhea, eczema, alopecia, associated with immunodeficiency
Sinus histiocytosis with massive lymphadenopathy Rosai-Dorfman disease A disease most common in adolescent blacks with massive cervical lymphadenopathy as well as enlargement of extranodal (orbit, skin, bone, salivary gland, testis) lymphoid tissues
Virus-associated hemophagocytic syndrome A condition induced by viral infections, often accompanied by abnormal liver function tests, coagulation assays and pancytopenia Pathology Histiocyte hyperplasia, hemophagocytosis and replacement of native bone marrow elements
Intermediate
Histiocytosis X, aka Langerhans' cell histiocytosis, see there.
Reactive hemophagocytic syndrome, see there.
Malignant
Histiocytic medullary reticulosis see there.
Histiocytic proliferations, eg—acute monocytic leukemia (FAB M3), histiocytic lymphoma see there, malignant histiocytosis–see there.
References in periodicals archive ?
Potential clinical implications of BRAF mutations in histiocytic proliferations.
Microscopically, the variable features of traumatic tongue lesions have been recognized by some authors and have been generally described as fibroblastic and histiocytic proliferations, which infiltrate between striated muscle bundles.
Compact mast cell aggregates should also be distinguished from monocytic nodules seen in myelodysplastic/myeloproliferative neoplasms and other histiocytic proliferations such as granulomas, especially when the compact mast cell aggregates are surrounded by lymphocytes.
13) The key features for distinction of malignant histiocytic entities from benign histiocytic proliferations, such as RDD, are significant cytologic atypia, pleomorphism, and evidence of tissue invasion or destruction.
Another pathology associated with histiocytic proliferation in bone marrow trephine biopsies (BM I B) and splenic tissue is haemophagocytosis.

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