histiocyte

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histiocyte

 [his´te-o-sīt″]
macrophage. adj., adj histiocyt´ic.

his·ti·o·cyte

(his'tē-ō-sīt'),
A tissue macrophage; the class includes hepatic Kupffer cells, alveolar macrophages, giant cells of granulomas, osteoclasts, and dermal Langerhans cells. These cells derive from precursors that normally reside in bone marrow but migrate through the bloodstream to egress into tissues for final differentiation.
Synonym(s): histocyte
[histio- + G. kytos, cell]

histiocyte

/his·tio·cyte/ (his´te-o-sīt″) macrophage.histiocyt´ic

histiocyte

(hĭs′tē-ə-sīt′)
n.
A macrophage or dendritic cell that is usually immobile and is found in organs and tissues.

his′ti·o·cyt′ic (-sĭt′ĭk) adj.

histiocyte

macrophage

A nonspecific immune defence cell that interacts with proteins and polysaccharide antigens, internalising and partially degrading them, and/or presenting the antigens to T cells in a major histocompatibility complex (MHC) context. Macrophages are involved in secretion, immune interaction with T and B cells and provide lymphokine receptors; once activated, macrophages are highly microbicidal and tumouricidal, often closely associated with the blood vessels, epithelium and mesothelium, which are appropriate sites for non-specific immunocytes.
 
Morphology
Large (15–80 µm in diameter), often with bleb-like or filiform pseudopodia; one (or rarely more) round to oval, occasionally indented nucleus; nuclear membrane is distinct; nuclear chromatin is fine with a reticular pattern; abundant, pale grey-blue, often granulated (coarse azurophilic granules) and vacuolated cytoplasm with phagocytosed material (RBCs, WBCs, platelets, nuclei, bacteria and remnants in native or degraded form).

his·ti·o·cyte

(his'tē-ō-sīt)
A macrophage present in connective tissue.
Synonym(s): histocyte.
[histio- + G. kytos, cell]

histiocyte

A fixed scavenging cell (phagocyte) found in connective tissue. Histiocytes are also known as reticuloendothelial cells and reticulum cells. A macrophage that does not migrate.

histiocyte

macrophage present in connective tissue

his·ti·o·cyte

(his'tē-ō-sīt)
A macrophage in connective tissue.
[histio- + G. kytos, cell]

histiocyte (his´tēəsīt´),

n a large phagocytic cell found in the interstices of the tissues; of reticuloendothelial origin.

histiocyte

a large phagocytic interstitial cell of the reticuloendothelial system; a macrophage.
References in periodicals archive ?
4) Moreover, in all of our patient's biopsies, the immunohistochemical studies were consistent with RDD, including CD68 and S100 protein labeling of histiocytes and lack of CD1a expression.
The hallmark of both lesions is the periodic acid-Schiff diastase-positive material in the cytoplasm of the histiocytes.
of Cases Free Leishman-Donovan bodies 9 Histiocytes 9 Granuloma 7 Acute and chronic inflammatory cells 6 Multinucleated giant cells 5 Mast cells 6 Binucleated histiocytes (Reed-Sternberg-like cells) 6 Plasma cells 11 Atypical organisms 1 Intrahistiocytic Leishman-Donovan bodies 9 Table 2.
B) Fite-stained section of a specimen from the chin highlights numerous acid-fast bacilli within histiocytes (original magnification x1,000); inset shows peripheral nerve involvement (arrows) that is diagnostic for leprosy (original magnification x1,000).
Microscopically, the lesion is characterized by dense aggregates of large mononuclear histiocytes (the 'von Hansemann' cells) admixed with intracellular and extracellular calcied granular inclusions known as Michaelis-Gutmann bodies and lymphoplasmacytic inltrate.
The pathological analysis of the nephrectomy specimen revealed an inflammatory infiltrate formed by foamy histiocytes that were positively stained for CD68 and neutrophilic aggregates which confirmed the preoperative diagnosis (Figures 4 and 5).
The presence of emperipolesis, or the engulfment of lymphocytes and erythrocytes by histiocytes that express S-100, is considered diagnostic of RDD.
The percentage of cells positive for CD1a or S-100 protein was comparable to percentages of Langerhans-like histiocytes stained with Giemsa stain.
FNAC of inguinal lymphnode was sparsely cellular with lymphocytes, a few plasma cells and scattered foamy histiocytes (Figure 2C).
Langerhans cell histiocytosis (formerly called histiocytosis X by Lichtenstein in 1953) refers to a group of disorders that are characterized by proliferation of cytologically benign histiocytes.
The disease commonly presents in children and young adults, with supradiaphragmatic lymphadenopathy or extranodal lesions consisting of tissue infiltrates composed of a polyclonal population of sinus histiocytes.
This further attracts histiocytes to phagocytize the insoluble cholesterol.