hippocampal sclerosis


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Related to hippocampal sclerosis: temporal lobe epilepsy

sclerosis

 [sklĕ-ro´sis]
an induration or hardening, especially of a part from inflammation, or in disease of the interstitial substance. The term is used chiefly for such a hardening of the nervous system due to hyperplasia of the connective tissue or for hardening of the blood vessels. Called also induration. adj., adj sclerot´ic.
amyotrophic lateral sclerosis see amyotrophic lateral sclerosis.
arteriolar sclerosis arteriolosclerosis.
disseminated sclerosis multiple sclerosis.
familial centrolobar sclerosis a progressive familial form of leukoencephalopathy marked by nystagmus, ataxia, tremor, parkinsonian facies, dysarthria, and mental deterioration.
focal glomerular sclerosis focal segmental glomerulosclerosis.
glomerular sclerosis glomerulosclerosis.
hippocampal sclerosis loss of neurons in the region of the hippocampus, with gliosis; sometimes seen in epilepsy.
lateral sclerosis a form seated in the lateral columns of the spinal cord. It may be primary, with spastic paraplegia, rigidity of the limbs, and increase of the tendon reflexes but no sensory disturbances, or secondary to myelitis, with paraplegia and sensory disturbance.
medial calcific sclerosis (Mönckeberg's sclerosis) Mönckeberg's arteriosclerosis.
multiple sclerosis see multiple sclerosis.
systemic sclerosis systemic scleroderma.
tuberous sclerosis a congenital heredofamilial disease, transmitted as an autosomal dominant trait, characterized principally by the presence of hamartomas of the brain (tubers), retina (phakomas), and viscera, mental retardation, seizures, and adenoma sebaceum, and often associated with other skin lesions.

hip·po·cam·pal scle·ro·sis

a loss of cortical neurons and a reactive astrocytosis in the hippocampal regions of some persons with epilepsy.

hippocampal sclerosis

A generic term for severe scarring and neuronal loss in the hippocampus, a finding seen in 65% of patients with temporal-lobe epilepsy.
 
Diagnosis
MRI.
References in periodicals archive ?
Hippocampal atrophy was present bilaterally, and histologic examination revealed severe bilateral hippocampal sclerosis with loss of neurons in subiculum and hippocampal sector CA1 and associated reactive astrogliosis (Figure 3, A through J).
Quantitative MRI reliable for detecting of Hippocampal sclerosis.
In patients with TLE with coexisting hippocampal sclerosis an increased activity of MMP-9, an elevated MMP-9 to TIMP-1 ratio and a high level of urokinase uPAR were reported.
Milesi et al., "Short- and long-term surgical outcomes of temporal lobe epilepsy associated with hippocampal sclerosis: relationships with neuropathology," Epilepsia, vol.
Hippocampal sclerosis were assessed with increased signal intensity on coronal FLAIR images and found to be unilateral in seven patients (4 in right TLE group; 3 in left TLE group) and bilateral in 5 patients (3 in right TLE group; 2 in left TLE group).
An association betwen mesial temporal lobe epilepsy with hippocampal sclerosis and human leucoycte antigens.
Hippocampal sclerosis is a progressive disorder: a longitudinal volumetric MRI study.
Lon White and colleagues asked the question: 'What is the cause of dementia in older people?'They found in their subjects from the Honolulu Aging Study and the Nun Study (average age 88 and 90 years, respectively) that an individual's dementia is the result of multiple pathologies, including Alzheimer's, vascular disease, Lewy body disease, and hippocampal sclerosis, rather than a single cause.
(11) On the other hand hippocampal sclerosis and idiopathic epilepsies are rare in late-onset epilepsies seen in our study, was also described by Stefan et al.
Dual pathology [sup][23] (cavernoma + hippocampal sclerosis), which means the coexistence of hippocampal sclerosis with extra-hippocampal lesion, Recurrent seizures can cause hippocampal sclerosis constantly and thus generate a new epileptogenic zone in the mesial part of temporal lobe.
The recent National Institute on Aging-Alzheimer's Association (NIA-AA) revision of criteria for the pathologic diagnosis of AD recommends a minimum of 13 histologic sections to evaluate for Alzheimer disease neuropathologic change (ADNC), Lewy body disease (LBD), vascular brain injury, microvascular lesions, and hippocampal sclerosis. (5,6) These same 13 sections may be used for the evaluation of FTLD.
"Drug-induced folate deficiency and enhanced GABA [gamma-aminobutyric acid] neurotransmission, especially in patients with hippocampal sclerosis, have been discussed as potential pharmacologic mechanisms of AED-induced depression and suicidality However, contradictory data indicate that GABA-active agents can be effective in treating depression."