conserved sequence

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conserved sequence

a NUCLEOTIDE SEQUENCE in a DNA or RNA molecule or an AMINO ACID SEQUENCE in a PROTEIN that has remained largely unchanged during evolution; the sequence being very similar between many species. Examples include sequences in PROMOTERS, RIBOSOMAL RNA, and in proteins involved in DNA REPLICATION. See also CONSENSUS SEQUENCE.
References in periodicals archive ?
Our genomic imprinting study focused on highly conserved sequence characteristics in the set of particular species being studied.
These reagents contain shorter highly conserved sequence regions improving assay specificity, and the probes are non-cleavable which allows post-PCR melt curve analysis.
Hammerhead ribozymes, as based on the Haseloff and Gerlach model (Nature, 1988), consist of a catalytic core made up of a highly conserved sequence of 24 nucleotides that cleave substrate RNAs.
The slow-evolving SSU rRNA is often the best marker for molecular phylogenetic analysis as it is ubiquitous with multiple copies highly conserved sequence and has exactly the same function in all cells.
By the advent of molecular technologies based on Polymerase Chain Reaction (PCR) for the ribosomal gene amplification is used for the genetic identification of many organisms because they comprise both highly conserved sequences during evolution and highly variable sequences among species.

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