high-dose chemotherapy


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high-dose chemotherapy

Oncology The administration of chemotherapeutics in excess of BM toxicity; given the risk of aplastic anemia, HDC requires autologous BMT and use of 'rescue' factors such as G-CSF, GM-CSF, and erythropoietin. See Bone marrow transplantation.
References in periodicals archive ?
Bajorin et al., "TI-CE high-dose chemotherapy for patients with previously treated germ cell tumors: results and prognostic factor analysis," Journal of Clinical Oncology, vol.
Pawlowska, "High-dose chemotherapy and stem cell rescue for high-risk Ewing's family of tumors," Expert Review of Anticancer Therapy, vol.
The results of the present study suggest that zinc-L-carnosine can also prevent the development of oral mucositis in patients with hematologic cancers who are receiving high-dose chemotherapy and radiation therapy followed by hematopoietic stem cell transplantation.
High-dose chemotherapy and autologous hematopoietic stem cell rescue therapy are promising in the treatment of CNS involvement.
Maintenance treatment after high-dose chemotherapy followed by ASCT in first-line treatment with rituximab prolonged EFS in either aaIPI 2 or 3 and CRu/PR subgroup, but there was no statistical significance, except for CR subgroup.
High-dose chemotherapy (HDCT) carries significant bone marrow toxicity, which leads to the necessity of autologous hematopoietic stem cell harvest and transplantation during treatment intensification.
Following a painful hip biopsy the toddler began a course of high-dose chemotherapy as his family were told he could face up to two years of hospital treatment.
Although BPDCN can be controlled for brief periods with standard chemotherapy, including high-dose chemotherapy with bone marrow transplantation, overall prognosis remains poor and the median overall survival from diagnosis is approximately 12 months.
Hooman Sadri-Ardekani, Ph.D in Reproductive Medicine and a Professor in Avicenna Institute-ACECR told the Iranian students news agency, "Young boys treated with high-dose chemotherapy are often confronted with infertility once they reach adulthood and cryopreserving testicular tissue before chemotherapy and auto transplantation of spermatogonial stem cells at a later stage could theoretically allow for restoration of fertility."
In this paper we examine the abandonment of high-dose chemotherapy followed by autologous hematopoietic stem cell transplantation (HDC/HCT) for women with breast cancer.
SCT is a frequently used treatment modality following high-dose chemotherapy and radiation therapy for hematologic cancers and other conditions in both adults and children.
After one bout of high-dose chemotherapy, Cash was so weak he could not lift his head and was too sick to eat any solid food for 40 days.

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