In 2014, we confirmed invasive Hib disease
in 3 Amish children from 2 different communities in Missouri; 2 patients had disease caused by the ST45 strain that was implicated in the 1999-2000 Hib cluster in Pennsylvania (Table).
In 97% of healthy unvaccinated adults, circulating IgG antibodies against Hib capsular polysaccharide were above the level ensuring longterm protection against invasive Hib disease
0 [micro]g/mL provide protection from invasive Hib disease
in the short- and long-term, respectively.
Following the introduction of the Hib glycoconjugate vaccine, the annual incidences of invasive Hib disease
and carriage (subclinical infection) in children aged <5 years decreased dramatically in countries where vaccination was implemented [8, 9].
A graph for Haemophilus influenzae type B vaccine (Hib), indicates that the incidence of invasive Hib disease
had decreased from 40-100 per 100,000 children in 1980 at the time of the introduction of the vaccine, down to fewer than 1 per 100,000 in 1990.
The EPI aims to protect children against nine vaccine preventable diseases; Polio, Tuberculosis, Pertussis, Hepatitis- B, Diphtheria, Tetanus, Hib disease
, Measles and pneumonia, of which pneumonia is the latest addition.
A routine vaccine is available to prevent Hib disease
For the Hib component of the Menhibrix vaccine, immune responses in infants and toddlers following vaccination with Menhibrix were found to be comparable to immune responses in infants and toddlers who received another FDA-approved vaccine against invasive Hib disease
It is reportedly the first combination vaccine to help prevent meningococcal serogroups C and Y and Hib disease
15) Additional surveillance data from Sweden show high VE against invasive Hib disease
, with incidences of 0.
Lone et al (1), have cautioned about the introduction of pentavalent vaccine, that also includes vaccine against Haemophilus influenzae type b (Hib), citing several studies in support of the lower Hib disease
burden in India, which stems from errors in interpretation of scientific literature.
There are still some cases of invasive Hib disease
immunization with conjugate Hib vaccine.