These receptors show different postsynaptic and presynaptic localizations and distributions in the brain and have different autoreceptor and heteroreceptor
characteristics as mentioned above.
La formacion de zonas de color amarillo producto de la superposicion de los espectros de emision del OxTR marcado con la proteina fluorescente GFP (verde) con el 5-HT1AR marcado con proteina fluorescente YFP (rojo) podria sugerir la formacion del heteroreceptor
Activities of the monohomomeric receptors: [5-HT.sub.1A], [GalR.sub.1], and GPR39, and the heteroreceptor
complexes: [5-HT.sub.1A]-GPR39 and [5-HT.sub.1A]-GPR39- [GalR.sub.1], were measured by their ability to activate response elements: the serum response element (SRE) and nuclear factor kappa beta response element (NF[kappa][beta]-RE) .
Zaghouani, "On the Role IL-4/IL-13 Heteroreceptor
Plays in Regulation of Type 1 Diabetes," The Journal of Immunology, vol.
Ambrogini et al., "Understanding the role of gpcr heteroreceptor
complexes in modulating the brain networks in health and disease," Frontiers in Cellular Neuroscience, vol.
It has been shown that the [H.sub.3] receptor functions as a heteroreceptor
, regulating the release of other central neurotransmitters, such as acetylcholine and serotonin, which can modulate learning and memory processes.
Fiordaliso et al., "Erythropoietin mediates tissue protection through an erythropoietin and common [beta]-subunit heteroreceptor
," Proceedings of the National Academy of Sciences of the United States of America, vol.
 Also, genetic studies with presynaptic GABA(B) heteroreceptor
knockout mice  and GAD65 (a GABA-synthesizing enzyme) knockout mice  found that these knockouts resulted in a generalized fear response.
Carbamylated EPO (CEPO) does not bind to the classical EPOR isoform, and is devoid of classic haematopoietic activity (5,30) (Table 1), yet has been shown to provide tissue protection in the brain, heart (31) and kidney (30), supporting the existence of a heteroreceptor
EPO isoform, which mediates tissue protection.
Synaptic transmission by endogenous neurotransmitters via autoreceptors or heteroreceptors
is modulated within neuronal circuits.
Over the long term, the brain tries to compensate for the SSRI-induced serotonin levels and restore energy homeostasis by decreasing serotonin production and activating 5-HT1A heteroreceptors
that inhibit the artificially excited neurons.
[17,18] They are believed to work through their antagonistic activity of central presynaptic [[alpha].sub.2] adrenergic inhibitory autoreceptors and heteroreceptors