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Related to heterodimer: Homodimer, Heterodimerize


A molecule composed of paired proteins with some amino-acid sequence variations.
[hetero- + dimer]
Farlex Partner Medical Dictionary © Farlex 2012
References in periodicals archive ?
Eukaryotic, MutS is asymmetric because of the presence of heterodimers MSH2-MSH6 and MSH2-MSH3.
Rabbit anti-s100A8 (1:200) s100A9 (1:200) or S100A8/S100A9 heterodimer (1:250) were applied overnight at 4[degrees]C.
In the liver, the heterodimer FXR/RXR, after binding retinoic acid and BS, induces the expression of SHP.
Previous studies have found that [[beta].sub.1]-AR and [[beta].sub.2]-AR could form heterodimers, although they also found that the autoantibody [[beta].sub.1]-AA did not bind to [[beta].sub.2]-AR [15].
Lack of [serine.sup.536] phosphorylation does not, however, preclude the p65 heterodimer from docking and transcribing other cytokines, the genes of which are equipped with the kappa-B nucleotide motif.
Tian et al., "Synthesis of heterodimer radionuclide nanoparticles for magnetic resonance and single-photon emission computed tomography dual-modality imaging," Nanoscale, vol.
When the expression of LXR[alpha] gene is increased, more heterodimers could be formed by PPARI3 and RXR, inhibiting PPARI3 and RXR forming heterodimers and decreasing the expression of PPARI3 (Yoshikawa et al., 2003).
[39] Recently, HIF-2[alpha] targeted antagonist, PT2399 is shown to impart antitumor activity in human renal cell carcinoma cell lines, and xenografts with higher expression of HIF-2[alpha] by dissociating HIF-2[alpha]/HIF-1[beta] heterodimer with decreased HIF-2[alpha] targeted genes.
This antibody detected the E1-E2 heterodimer of LV (75 kDa) as well as the E2 monomer (50 kDa) in Western blot analysis, although the reactivity against BVDV-1 E2 was much stronger (Figure 2, panel A).
Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.
Association of IL-12p35 and IL-12p40 subunits forms the bioactive heterodimer of 70-75 kDa (IL-12p70 or alternatively IL-12p75).
In the "trans-signaling" axis, circulating IL-6 forms a heterodimer with the soluble form of IL-6 receptor, IL-6/sIL6R, that could transduce a proinflammatory cascade in virtually any cell types through direct binding with membrane-bound gp130.