genetic disorder

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genetic disorder

n.
A pathological condition caused by an absent or defective gene or by a chromosomal aberration. Also called hereditary disease.

ge·net·ic dis·or·der

(jĕ-net'ik dis-ōr'dĕr)
A widely used but nonetheless imprecise term that denotes a condition or illness related to biologic inheritance.

Patient discussion about genetic disorder

Q. what makes Arthritis a genetic disease?

A. First of all, the term arthritis is a bit inaccurate: Arthritis denotes an inflammation of joints. There are many kinds of arthritis that may result from different causes, and therefore, are different diseases: septic arthritis (inflammation due to infection of joint) has much less genetic background than ankylosing spondylitis (an arthritis of the lower back joints that occurs almost exclusively in people with certain genetic background).

The arthritis with the genetic background are usually the autoimmune ones: Due to genetic determinants, the immune system of some people is programmed to recognize the various parts of the joints (and other organs as well) as foreign (i.e. like bacteria) and thus launches an attack on them. In normal immune system, that doesn't happen.

You may read more here:
http://en.wikipedia.org/wiki/Autoimmune_disease

Q. Is bipolar disease a hereditary problem? My only son is in his teens that is the age to enjoy life, but he cannot enjoy his life with his friends because we found that he is suffering from a bipolar condition. I feel so sad for him and though my care-free days have gone, I often think about how much fun I had at his age. I too suffered from a bipolar disorder and my mom too. Is bipolar disease a hereditary problem? I want him to help to enjoy his life.

A. I agree with you. No one should suffer because of hereditary problems. This is the same situation here as genes are passed from generation to generation. This information is inconclusive because many who may have had bipolar disorders did not have it checked out. Who is to say, how many people 50 years ago had it but dismissed it as being moody, or ill tempered. Doctors were not aware about this problem years ago. Some time back, someone who showed signs of a mental disorder was straight away shoved into a mental hospital and left to suffer. Besides they are often treated with electric shock therapy eventually getting out of control. Testing is still in progress to find out if genetics play a role but these theories may take several more years before they can have a better understanding.
http://www.youtube.com/watch?v=f7uKg7ujoig&eurl=http://www.imedix.com/health_community/vf7uKg7ujoig_film_mental_illness_released_strive_happiness?q=bipolar%20disease%&feature=player_embedded

Q. Is FMS heredetery? My mother was diagnosed with FMS and I would like to know what are the chances I’ll have it too.

A. Hereditary is not the right term. It’s not a genetic disease but The cause of fibromyalgia remains elusive. However, recent studies show that genetic factors can predispose individuals to a genetic susceptibility to fibromyalgia.

More discussions about genetic disorder
References in periodicals archive ?
By following a multidisciplinary approach that combined classic plant pathology with next-generation DNA sequencing and computational analysis of gene expression and DNA methylation data, we identified and characterised four epigenetic loci that control heritable disease resistance," he said.
The first application refers to correcting the heritable disease in a manner that would eradicate the risk to subsequent generations and would be undertaken at the earliest possible embryonic stage.
A chapter is devoted to the use of iPSCs grown in vitro to study heritable disease, specifically arrhythmogenic heart disease, at a patient-specific level.
The Secretary's Advisory Committee on Heritable Disease in Newborns and Children (SACHDNC), which was formed in 2003 to advise the Secretary of the Health and Human Services (HHS) on newborn screening, was tasked with the development of a national recommended panel for newborn screening conditions to be included on state panels.
Classical genetic studies proved that schizophrenia is a highly heritable disease. Genetic make-up of this psychiatric disorder is being thoroughly explored for improvement of diagnostic methods and therapeutic targets.
Being able to offer genetic counseling and testing before conception gives couples more time and options if they are at risk for heritable disease, according to the ACOG policy For example, couples may choose not to conceive, use a gamete donor, or obtain preimplantation genetic diagnosis.
Furthermore, we are learning that the genetic disease risk defined by single-nucleotide variants often only accounts for a small portion of the overall heritable disease risk.
Heritable disease A disease that is genetically inherited from one or more parent.
This effort marks the first utilization of an indigenous Louisiana population in the explication of a heritable disease in humans.
The (http://file:///C:/Users/ADMIN/Downloads/24623.pdf) report , drafted by scientists at the National Academy of Sciences and the National Academy of Medicine, outlines three areas where human genome editing can be used - basic science research in labs; altering somatic, or non-reproductive, cells for purposes of treating or preventing disease; and altering an individual's germline, or reproductive, cells to treat and prevent heritable disease.
"We not only have confirmed that this is a heritable disease, which occurs in some form in nearly 50% of the population, but now we know which genes play a large role--and that gives us pretty interesting clues about how the disease works and what we can do to better treat and prevent it."
In addition to providing estimates of heritable disease risk, a careful family history can provide insights on family dynamics, shared environmental factors, and patient health concerns.