PTG-300 is an injectable hepcidin
mimetic in development for the treatment of iron overload anemia and related rare blood diseases.
, Anaemia, Iron metabolism, Iron, Inflammation.
Roxadustat is a hypoxia-inducible factor prolyl hydroxylase inhibitor that promotes erythropoiesis by increasing endogenous production of erythropoietin and improving iron regulation, and overcoming the negative impact of inflammation on haemoglobin synthesis and red blood cell production by downregulating hepcidin
. Administration of roxadustat has been shown to induce coordinated erythropoiesis, increasing red blood cell count while maintaining plasma erythropoietin levels within or near normal physiologic range, in multiple subpopulations of CKD patients, including in the presence of inflammation, and without a need for supplemental intravenous iron.
15 years since hepcidin
. Gastroentrology 2015(149): 1240-51.
Base-line values of ferritin, hepcidin
, sTfR-index (Soluble transferrin receptor) and RBC-He (Hb content of RBC) also predicted the hematopoietic response, but to a lesser degree, according to their study.
is an acute-phase reactant protein synthesized in the liver.
and chemerin are some of the antimicrobial proteins.4 Hepcidin
is a recently discovered hormone which is synthesized in the liver and is an antimicrobial protein displaying antibacterial and antifungal properties and maintains iron balance in the microorganism thus regulating its metabolism.
Although the mechanism is not completely understood, it is believed that RDW is associated with IL-6, tumor necrosis factor, hepcidin
, and other cytokines in the circulation which affect the biological behavior of tumor cells (21,22).
Vitamin D receptor expression and hepcidin
in the protection or severity of leprosy: a systematic review.
Iron absorption is inhibited by the hormone hepcidin
, released from the liver when iron levels are adequate or high.
On the one end, the demand for iron during pregnancy substantially increases due to expansion of maternal blood volume and rapid growth of placenta and fetus.,, Those women with higher BMI before pregnancy may have more iron stores for compensating the iron consumption during pregnancy and appear to less likely develop ID during pregnancy. On the other end, overweight, particularly obesity, is associated with underlying systemic inflammation, and the resulting elevation of hepcidin
and serum ferritin,, may decrease iron absorption from dietary, and hemoglobin production., Thus, the overweight and obesity status may be associated with increased risk of IDA.
M2 PHARMA-September 28, 2018-Protagonist Therapeutics wins US FDA's Fast Track Designation for Hepcidin
Mimetic PTG-300 for chronic anaemia with beta-thalassemia