1 mL of silymarine solution (100 [micro]g/mL) followed by respective hepatotoxin
Structures of three new cyclic hepatotoxins
produced by the cyanobacterium (blue-green alga) Nostoc sp.
attack a protein in the membranes of liver cells, says Ken Frazier, a pathologist at the University of Georgia's Veterinary Diagnostic and Investigational Laboratory in Tifton.
In addition, there are many variants of hepatotoxins
(more than 50 microcystins have been recognized, for example), each with its own toxicity.
Acute oral toxicity of microcystin-LR, a cyanobacterial hepatotoxin
, in mice.
8] Hepatotoxic substances may be a hazard for people working in a number of occupations, including textile and dye manufacturing and painting; patients who are known to be exposed to these hepatotoxins
should be screened.
We, as well as many other groups, have been [able] to manipulate the cultured hepatocytes in ways that are quite impossible with an intact animal to probe the mechanisms of irreversible injury by hepatotoxins
," he says.
Further studies are required to know the exact molecular mechanism by which the icetexane diterpenes induce apoptosis and protect liver from hepatotoxins
Notable among such toxins for humans are neurotoxins and hepatotoxins
microcystins) that are known neurotoxins and hepatotoxins
The differential diagnosis for serum alanine transaminase and serum aspartate transaminase levels in the thousands includes a very short list of drugs, exposure to hepatotoxins
such as carbon tetrachloride, and viral hepatitis.
If higher enzymes are noted, one should look for additional hepatotoxins
such as acetaminophen use or coexistent viral hepatitis.