Therefore, we supposed miR-155 would over-express in KCs and/or hepatocytes
At 400X the pyknotic necrosis of hepatocytes
with cytoplasmic vacuolization were also noted.
Prooxidant-initiated lipid peroxidation in isolated rat hepatocytes
: detection of 4-hydroxynonenaland maloneialeehyee-protein adducts.
The functional life of hepatocytes
may be prolonged by a variety of techniques.
With HepatoMune, the micropatterned primary hepatocytes
and fibroblasts are supplemented with primary Kupffer cells, creating highly functional human liver tissue that models inflammation-mediated hepatotoxicity.
Therefore, when conducting pharmacokinetic studies, it was assumed that hepatocyte
concentrations approximate plasma concentrations, with the drug equilibration across the sinusoidal membrane being obtained by passive diffusion.
animal sources have been proposed and investigated as alternatives to human hepatocytes
, including human tumor cell lines, immortalized hepatocytes
from pig livers, and hepatocytes
from transgenic pigs .
Total RNA, including short RNAs, was purified from frozen hepatocytes
(pooled 10 donors HMCS10, GIBCO) and cells harvested at two different time points: day 20 of hepatic differentiation (hepatoblast stage of HD) and day 24, the last day of differentiation, using the miRNeasy Micro Kit (Qiagen) and quantified by NanoDrop spectrophotometer.
Flavell, "Interleukin-22 but not interleukin-17 provides protection to hepatocytes
during acute liver inflammation," Immunity, vol.
 demonstrated that the scaffolds immobilized by galactose retained a greater number of hepatocytes
than those scaffolds which were unmodified or immobilized with galactose, due to specific interactions between hepatocytes
and galactose moieties.
Primary human hepatocytes
are the FDA agreed-upon gold standard.
The liver, composed of parenchymal cells--hepatocytes--and nonparenchymal cells including endothelial cells, Kupffer cells, lymphocytes, and stellate cells, has a unique capacity to precisely regulate its growth and mass, which is particularly remarkable since hepatocytes
are stable cells and rarely divide in the normal state, as they are quiescent in the G0 phase of the cell cycle .