CD44

(redirected from Heparan Sulfate Proteoglycan)
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CD44

a type I transmembrane protein present on T cells, pre-B cells, monocytes, neutrophils, CNS white matter, fibroblasts, skeletal muscle, and medullary thymocytes; facilitates lymphocyte binding to endothelial venules and assists in adhesion.

CD44

A gene on chromosome 11q13 that encodes a cell surface glycoprotein involved in cell–cell interactions, cell adhesion and cell migration, and which is a receptor for hyaluronic acid. CD44 also interacts with other ligands—e.g., osteopontin, collagens and matrix metalloproteinases—and participates in a range of cellular functions including lymphocyte activation, recirculation and homing, haematopoiesis and tumour metastasis.
References in periodicals archive ?
Syndecan-2 is but one member of the syndecan family of heparan sulfate proteoglycans.
2005) and has shown alteration in its expression pattern in response to other syndecan isoforms or other heparan sulfate proteoglycans as embryogenesis proceeds.
Loss of heparan sulfate proteoglycan from glomerular basement membrane of nephrotic rats.
Decreased glomerular basement membrane heparan sulfate proteoglycan in essential hypertension.
Control of growth factor networks by heparan sulfate proteoglycans.
Functions of heparan sulfate proteoglycans in cell signaling during development.
Heparan sulfate proteoglycans including syndecan-3 modulate BMP activity during limb cartilage differentiation.
It has been reported that EL has several heparin-binding domains and binds to heparan sulfate proteoglycans on the vascular endothelium (12, 15, 40).
VEGF in mouse has three isoforms, VEGF 120, 164, and 188, that differ in their ability to bind heparan sulfate proteoglycans on the cell surface and in the extracellular matrix (ECM) (4, 5).
Differential expression of cell surface heparan sulfate proteoglycans in human mammary epithelial cells and lung fibroblasts.