Iron is a highly reactive metal; thus, to reduce metal toxicity, iron is maintained bound to hemoproteins
and in iron-sulfur clusters or safely stored in ferritin cages .
Electron transfer between a tyrosyl radical and a cysteine residue in hemoproteins
: spin trapping analysis.
In contrast to cobalt and iron protoporphyrin, ZnPP was found to affect neither heme biosynthetic enzymes nor cellular actions that depend on hemoproteins. These findings led to the conclusion that ZnPP may be useful as an experimental tool for the selective suppression of heme degradation (41, 43).
CO production in mammals is at least 85% attributable to the HO-mediated degradation of hemoprotein heme (58, 59).
The steady-state level of hepatic heme is the net result of biosynthesis, degradation, and incorporation of heme into hemoproteins
within the liver.
The colour of raw meat comes from its hemoproteins, principally myoglobin.
Application of this protected pigment to a variety of emulsion-type muscle foods ranging from cod surimi to seal meat containing up to 9% hemoproteins, has been accomplished.[9,21] Table 2 summarizes the quantity of CCMP required to mimic the color effects of muscles treated with sodium nitrite.
Many of the oxidoreductases genes encode hemoproteins. Remarkably, we found that expression of Alas1, the rate-limiting enzyme in the heme synthetic pathway, was upregulated in the liver tissue of the young Bach1-deficient mice (Figure 6(e)).
Takaku et al., "Hemoprotein Bachl regulates enhancer availability of heme oxygenase-1 gene," EMBO Journal, vol.
Plant peroxidases, like Hb, are hemoproteins
that have the prosthetic group ferriprotoporphyrin IX (hemin) (5).