hemophagocytosis

he·mo·phag·o·cy·to·sis

(hē'mō-fag'ō-sī-tō'sis),
The process of engulfment (and usually destruction) of blood cells by the various types of phagocytic cells; used especially with reference to the engulfment of erythrocytes and others of the erythroid series.

hemophagocytosis

(hē″mō-făg″ō-sī-tō′sĭs) [″ + ″ + ″ + osis, condition]
The ingestion of red blood cells by phagocytes.
References in periodicals archive ?
In literature KD has been reported in association with systemic lupus erythematosis (SLE), Epstein Bar virus (EBV), hemophagocytosis with a common presentation of fever and lymphadenopathy.2-4 The pathogenesis of Kikuchi disease in unclear but histological changes suggests immune response with presence of T cells and exposure to infectious agents with histiocytes.
PIDs can also occur with autoimmunity, autoinflammatory or hemophagocytosis syndromes (3).
In addition, activated macrophages are sometimes noted to phagocytose erythrocytes, hence the term hemophagocytosis (13).
Significantly increased histiocytes (Figure 1b, highlighted by CD68 immunohistochemistry stain, brown color, arrows) with hemophagocytosis, macrophages engulfing lymphocytes, and cell debris in the cytoplasm (Figure 1c, Liu stain, arrow) were demonstrated.
The etiology of secondary HLH includes infection (especially Epstein-Barr virus infection), autoimmune diseases, and malignancies.[5] The pathological features of HLH are mononuclear macrophages and tissue cells from the bone marrow, spleen, liver, or lymph nodes phagocytose hemocytes which form a phenomenon of hemophagocytosis. A trail guideline in 2004 suggested that treatment can be divided into initial and maintenance periods for the first 8 weeks based on dexamethasone, etoposide, and cyclosporine, and then intrathecal injection can also be given.
(2) Hemophagocytosis or emperipolesis by neoplastic cells can be present.
Hemophagocytosis is the engulfment of hematopoietic cells by activated macrophages in tissue specimens.
A bone marrow biopsy demonstrated a hypercellular bone marrow with reactive changes and increased histiocytes with hemophagocytosis. The patient met diagnostic criteria for HLH, including fever, splenomegaly, cytopenia, hypertriglyceridemia, hypofibrinogenemia, hemophagocytosis in bone marrow, and elevated ferritin.
Secondary hemophagocytosis was also considered in the differential diagnosis because increased ferritin level was found in association with fever, pancytopenia, and splenomegaly.
The next common cause in this study was found to be dengue fever (21.7%) which may be due again to hypersplenism, hemophagocytosis, or immune hemolysis.