hemoglobin A2


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he·mo·glo·bin A2

[MIM*141850]
the normal Hb (Hb A2) of the formula α2Aδ2 or α2δ2, which makes up approximately 2.5% of the total adult hemoglobin concentration. At least 18 mutant variants of the δ chain have been reported.
Farlex Partner Medical Dictionary © Farlex 2012
References in periodicals archive ?
Other data included hemoglobin (Hb), MCV, MCH, mean corpuscular hemoglobin concentration (MCHC), hemoglobin F (HbF) and hemoglobin A2 (HbA2).
Hemoglobin A2' (Hb A2[delta]') in the Mauritanian population: first results of a preliminary survey.
An evaluation of the methods for quantitation of hemoglobin A2. Results from a survey of 10,663 cases.
The detection and diagnosis of hemoglobin A2' by high-performance liquid chromatography.AmJ Clin Pathol 2005; 123:657-61.
Subsequent hemoglobin electrophoresis revealed 17.5% of hemoglobin A (normal 94%-98%), 7.2% of hemoglobin A2 (normal 0.7%-3.1%), 73.8% of hemoglobin S (normal 0%), and 1.5% of hemoglobin F (normal 0-2%), which was suggestive of sickle cell beta-plus thalassemia.
Values Baseline Final Parameters Mean 95% CI Mean 95% CI Mean variation Blood count before and after one RCE (N Red cells count 3,1 2,9-3,3 3,3 3,1-3,4 +0,2 ([10.sup.12]/L) Hemoglobin rate 8,9 8,6-9,1 10,3 8,5-12,2 +1,4 (g/dL) Hematocrit (%) 26,2 24,7-27,8 30,6 23,3-37,6 +4,4 White cells count 11,5 10,7-12,2 11,6 10,4-12,7 +0,1 ([10.sup.9]/L) Platelets count 443 414-473 433 401-475 -10 ([10.sup.9]/L) Fractions of hemoglobin before and after 2 RCE performed the day of admission (N = 12) Hemoglobin S (%) 84,8 80,5-89 24,8 20,6-32 -60 Hemoglobin A (%) 0 -- 64 58-70 +64 Hemoglobin F (%) 10,2 8,0-12,5 6 3,0-7,5 -4,2 Hemoglobin A2 (%) 3,3 2,9-3,7 2,3 1,9-3,0 -1
Hemoglobin A2 of more than 3.5% was considered diagnostic for beta-thalassemia trait.
Phenotypic expression of hemoglobin A2 in beta-thalassemia trait with iron deficiency.
The range of hemoglobin A2 in hemoglobin E heterozygotes as determined by capillary electrophoresis.
del Pilar Aguinaga, "Chromatographic measurements of hemoglobin A2 in blood samples that contain sickle hemoglobin," Annals of Clinical & Laboratory Science, vol.
A small percentage of hemoglobin A2 and hemoglobin F is also present in the population, Hemoglobin F is predominately in fetuses and newborns.
Hemoglobin A2 was analyzed by micro column technique from Bio Systems kits and hemoglobin F was assayed by alkaline denaturation technical.