Finally, because of their central role in trophoblast invasion into the uterine endometrium, which is essential for proper
hemochorial placentation, the volume density and the absolute volumes of TGC and glycogen cells were determined.
Endometrial stromal cells were selected as a model of the maternal compartment because of the
hemochorial type placentation in humans.
The invasive nature of
hemochorial placentation implies direct contact between maternal and fetal cells.
Soares, "Natural killer cells direct
hemochorial placentation by regulating hypoxia-inducible factor dependent trophoblast lineage decisions," Proceedings of the National Academy of Sciences of the United States of America, vol.
Notable characteristics unique to humans and the Great Apes include deep interstitial implantation and a highly invasive
hemochorial phenotype thus allowing the direct interaction of maternal blood and fetal chorionic tissues [56].
