hemidesmosomes


Also found in: Encyclopedia.

hem·i·des·mo·somes

(hem'ē-des'mō-sōmz),
Adhering junctions that occur on the basal surface of the stratum basale of stratified squamous epithelium.

hem·i·des·mo·somes

(hem'ē-des'mō-sōmz)
Half desmosomes that occur on the basal surface of the stratum basale of stratified squamous epithelium.

hemidesmosomes

areas of thickened cellular membrane where filaments attach cells to the basal lamina, and transmembrane elements link the extracellular matrix to intracellular microfilaments; part of the cellular cytoskeleton
References in periodicals archive ?
Integrin alpha 6/beta 4 complex is located in hemidesmosomes, suggesting a major role in epidermal cell-basement membrane adhesion," Journal of Cell Biology, vol.
Unlike adherens junctions, hemidesmosomes affix the basal plasma membrane to the tissue's basal membrane (cell-extracellular matrix junction) via integrins a6P4 and laminin 5 filaments.
Hemidesmosome formation, which was observed along the collagen fibres and extensions, was demonstrated.
The functional integrity of horn depends on effective epidermal adhesion and this involves proteins such as cadherins and hemidesmosomes which connect cells to the basement membrane with anchorage by proteins such as integrins.
The authors described this tumor as consisting of intimately associated cells that contained complicated interdigitating processes, desmosomes, and hemidesmosomes, thus creating a jigsaw pattern.
26) Instead, the junctional epithelium is present in these areas and consists of hemidesmosomes and basal lamina.
The thin basal processes of these cells span the height of the epithelium and are linked to the basal lamina by hemidesmosomes.
Papers cover elementary integrin signaling, integrin signaling through focal adhesion kinase, the Paxillin family and tissue remodeling, adhesion dynamics in motile cells, integrin trafficking, hemidesmosomes and their components (adhesion v.
Viable cells break away from their support in a complex process involving signal transduction mechanisms (from inside to outside the cell) that result in conformational changes of the extracellular domain of desmosomes and hemidesmosomes [8].
Investigative efforts led to the identification of an immunoglobulin G (IgG) autoantibody, which binds to bullous pemphigoid (BP) antigen 2, also called BP180, which is a protein associated with hemidesmosomes of basal keratinocytes.
Investigative efforts lead to the identification of an immunoglobulin G (IgG) autoantibody, which binds to bullous pemphigoid (BP) antigen 2, also called BP180, which is a protein associated with hemidesmosomes of basal keratinocytes.