heme oxygenase

(redirected from Heme oxygenase-1)
Also found in: Acronyms.

heme oxygenase

,

HO

An enzyme that cleaves the ring structure of heme, releasing biliverdin, carbon monoxide, and iron. It is present in humans in two active forms: HO-1 and HO-2.
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
Vitamin C treatment attenuates hemorrhagic shock related multi-organ injuries through the induction of heme oxygenase-1. BMC Complement Altern Med 2014; 14: 442, doi: 10.1186/1472-6882-14-442.
Heme oxygenase-1 prevents airway mucus hypersecretion induced by cigarette smoke in rodents and humans.
Nakanishi, "Heme oxygenase-1 deficiency: the first autopsy case," Human Pathology, vol.
Choi, "Protective functions of heme oxygenase-1 and carbon monoxide in the respiratory system," Antioxidants and Redox Signaling, vol.
Chau, "Expression of heme oxygenase-1 in atherosclerotic lesions," The American Journal of Pathology, vol.
Song, "A heme oxygenase-1 transducer model of degenerative and developmental brain disorders," International Journal of Molecular Sciences, vol.
Bartz et al., "Heme oxygenase-1 couples activation of mitochondrial biogenesis to anti-inflammatory cytokine expression," Journal of Biological Chemistry, vol.
Bach, "Heme oxygenase-1: from biology to therapeutic potential," Trends in Molecular Medicine, vol.
Evidence shows that upregulation of heme oxygenase-1 (where HO-1 is an inducible enzyme that has a capacity to produce CO from the destruction of heme) within the CNS imparts stability against oxidative as well as other stresses [138].
These authors further showed that a defect in iron recycling accounts for dysregulation of iron homeostasis in human with heme oxygenase-1 deficiency [17].
Liby, "The synthetic triterpenoids, CDDO and CDDO-Imidazolide, are potent inducers of Heme oxygenase-1 and Nrf2/ARE signaling," Cancer Research, vol.
Heme oxygenase-1 (HO-1), which is expressed in all tissues, receives electrons from NADPH by P450 enzyme fractions due to CRP microsomal protein mediator and P450 protein-to-protein interactions [103].