heme oxygenase


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heme oxygenase

,

HO

An enzyme that cleaves the ring structure of heme, releasing biliverdin, carbon monoxide, and iron. It is present in humans in two active forms: HO-1 and HO-2.
References in periodicals archive ?
The heme oxygenase activity, the synthesizing rate determining enzyme for biliverdin formation, was measured by adding substrates in vitro and its products analyzed using the HPLC method.
We also observed an apparent increase in the expression of heme oxygenase in methoprene-exposed Day 1 Stage I larvae and postmolt juveniles.
in hypertensive rats, at least partially, resulted due to targeting heme oxygenase system.
Aronia melanocarpa fruit extract strongly increased the expression of heme oxygenase (HO-1) diminished by angiotensin II - by 18.
49) Resveratrol acts as a powerful antioxidant, scavenging oxygen free radicals and inducing protective enzymes such as heme oxygenase.
Article topics include an overview of the involvement of stress proteins in renal diseases and the relationship to glomerular epithelial cell injury, responses of renal medullary cells to osmotic stress, heat shock proteins in renal cell carcinomas, heat shock protein 47 and renal fibrogenesis, cytoprotective effects of heme oxygenase in acute renal failure, cisplatin-associated nephrotoxicity and pathological events, heat shock proteins and allograft rejection, and oxidant stress in renal pathophysiology.
As the major component of hemoglobin, heme can be degraded into iron, carbon monoxide, and biliverdin by heme oxygenase (HO).
Recent study indicates also that only complexes of haemoglobin with haptoglobin 1-1 induce expression of CD163, interleukin 10 (IL-10) and heme oxygenase 1 (HO-1) providing anti-inflammatory cardiovascular protection (Graversen et al.