With 18
hemagglutinin varieties and 11 types of neuraminidase -- most carried by birds -- there are lots of potential combinations.
A two-amino acid change in the
hemagglutinin of the 1918 influenza virus abolishes transmission.
It looks like these antibodies need to cross-link two
hemagglutinins to have maximum effect," said Wilson.
A fourth change in
hemagglutinin may affect how well the virus can fuse with cells in ferret--and presumably human--hosts.
2000) Early alterations of the receptor-binding properties of H1, H2, and H3 avian influenza virus
hemagglutinins after their introduction into mammals.
Its N-terminal sequence, ATETYSAFQRFCETNIFIQR, resembled those of other Phaseolus
hemagglutinins (Table 2).
Prediction of possible mutations in H5N1
hemagglutinins of influenza A virus by means of logistic regression.
High levels of IgG against H1 and H3
hemagglutinins were detected in the 2 control groups, as were GMT values of 2,070.
The virus's
hemagglutinin molecules append itself to the surface of cells lining the respiratory tract.
WB analysis of pooled samples from the 3 areas confirmed the ELISA results that showed antibodies against the
hemagglutinin and nucleoprotein antigens; however, samples from Manabi region (7,8) showed immunoreactivity to the H3 antigen only (Figure 2).
Hemagglutinins of the influenza A(H3N2)v viruses differed substantially from the
hemagglutinin of the 2011-12 human seasonal vaccine virus, A/Perth/16/2011 (58-60 aa), which resulted from divergent evolutionary paths for the H3
hemagglutinin in swine and human viruses.
However, no serologic evidence indicates that residue 107 modulates the antigenicity of human, porcine, or equine H3
hemagglutinins.
