hemagglutination inhibition

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he·mag·glu·ti·na·tion in·hi·bi·tion

inhibition of nonimmune hemagglutination by antibody specific for the hemagglutinin; for example, viral hemagglutination will not occur if antibody specific for the virus is added before addition of red blood cells. The inhibition is specific and is widely used for virus identification and for antibody determination.
Farlex Partner Medical Dictionary © Farlex 2012

hemagglutination inhibition

A laboratory test in which the lack of agglutination (clumping) of red blood cells (RBCs) indicates that antibodies are present in the patient's blood. Certain viruses (e.g., mumps, measles, rubella, adenovirus) bind with RBCs and cause clumping. However, antibodies, if present, quickly bind with the virus, preventing viral binding to RBCs and the resulting agglutination. See: agglutination
See also: inhibition
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
As a way to test if the attachment of virus to the cells is the point of inhibition, we performed the hemagglutination inhibition assay, which showed that pomegranate inhibits agglutination of chicken RBCs by influenza A virus (Fig.
All participants showed early antibody seroprotection, defined as postvaccination hemagglutination inhibition (HAI) antibody titer greater of at least 40, with similar rates of seroconversion between the heart failure patients and the healthy controls.
It's estimated that in the pediatric population there was an overall 50% reduction in the hemagglutination inhibition (HI) reaction to the H3N2 component of the vaccine.
Hemagglutination inhibition titers of influenza A(H3N2) viruses with serum specimens from infected ferrets (*)
We screened these samples by hemagglutination inhibition (HI) and microneutralization (MN) assays as described in the World Health Organization Manual for the Laboratory Diagnosis and Virological Surveillance of Influenza (10) (online Technical Appendix, https://www.nc.
This single synthetic vaccine shot resulted in the generation of a four-fold or greater rise in hemagglutination inhibition (HAI) titers in 50% of boosted subjects in its Phase I clinical study.
Using multiple assay techniques, including hemagglutination inhibition, microneutralization, and single radial hemolysis assays, as well as confirmatory Western blot analysis, the investigators found no evidence of seroactivity in the individuals exposed to the H7N1 virus, while 7 of the 185 samples from the H7N3-exposed group were "clearly and concordantly reactive, showing evidence of infection with or exposure to H7 viruses." Of the seropositive individuals, all of whom reported having had close direct physical contact with either turkeys or chickens in dusty poultry housing, only one reported clinical symptoms of conjunctivitis at the time of the epizootic and none reported a history of influenzalike illness.
The study also achieved its primary outcome of comparability of hemagglutination inhibition (HAl) titers.
Antigenic characterization of type A(H3N2) influenza viruses, by hemagglutination inhibition
We performed a hemagglutination inhibition assay by using APMV-1, APMV-2, APMV-3, APVA, and APVC antisera against isolates confirmed.
In pre-clinical studies, vaccination with VGX-3400 generated broadly protective levels of hemagglutination inhibition (HAI) titers in 100% of the immunised animals in five separate animal models - mice, ferrets, rabbits, pigs, and rhesus monkeys.
Significantly higher hemagglutination inhibition titers to influenza B also were seen in the active treatment group (J.

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