haemochromatosis

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he·mo·chro·ma·to·sis

(hē'mō-krō-mă-tō'sis)
A disorder of iron metabolism characterized by excessive absorption of ingested iron, saturation of iron-binding protein, and deposition of hemosiderin in tissue, particularly in the liver, pancreas, and skin; cirrhosis, diabetes mellitus (bronze diabetes), bronze pigmentation of the skin, and, eventually heart failure may occur; also can result from administration of large amounts of iron orally, by injection, or in forms of blood transfusion therapy.
Synonym(s): haemochromatosis.
[hemo- + G. chrōma, color, + -osis, condition]

haemochromatosis

A rare genetic disease featuring abnormal absorption and retention of iron. Total body iron may rise from the normal 4 or 5 g to as much as 60 g and the stored iron may cause CIRRHOSIS of the liver, DIABETES, IMPOTENCE, HEART FAILURE and bronzing of the skin. Treatment is by regular weekly bleeding until the levels of serum iron reach normal. The drug desferrioxamine is also useful.

he·mo·chro·ma·to·sis

(hē'mō-krō-mă-tō'sis) [MIM*235200]
Disorder of iron metabolism characterized by excessive absorption of ingested iron, saturation of iron-binding protein, and deposition of hemosiderin in tissue, particularly in the liver, pancreas, and skin; cirrhosis, diabetes (bronze diabetes), bronze pigmentation of the skin, and, eventually heart failure may occur; can also result from administration of large amounts of iron orally, by injection, or in forms of blood transfusion therapy.
Synonym(s): haemochromatosis.
[hemo- + G. chrōma, color, + -osis, condition]
References in periodicals archive ?
In hereditary conditions such as hemachromatosis, a concurrent insult such as alcohol ingestion will increase injury and rate of progression to fibrosis (Friedman 1993).
The tests available on these seven sites included hereditary hemachromatosis, [[alpha].sub.1]-antitrypsin deficiency, cystic fibrosis carrier status, and a pharmacogenetic test for certain cytochrome p450 alleles.
The tests available on these seven sites included hereditary hemachromatosis, [[alpha].sub.1]-antitrypsin deficiency cystic fibrosis carrier status, and a pharmacogenetic test for certain cytochrome p450 alleles.
Transferrin receptor function in hereditary hemachromatosis. J Lab Clin Med 1984; 103:246-54.
Part of the reason for the move, originally sponsored by Orrin Hatch, R-Utah, and Ted Kennedy, D-Mass., in the original Senate bill, was a recurring flap over iron supplementation and hemachromatosis. The net result was to move dietary supplements out of FDA's control as drugs.
Several of the papers that were presented as part of this Beckman Conference also describe approaches that can be used to evaluate patients with possible liver disease, ranging from screening for hemachromatosis to evaluating patients with possible hepatitis.
Issues concerning screening for disease are presented well in Witte's paper dealing with hereditary hemachromatosis [7].