Held


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Held

(held),
Hans, German anatomist, 1866-1942. See: Held bundle, Held decussation.

ARID1A

A gene on chromosome 1p36.1-p35 that encodes AT-rich interactive domain-containing protein 1, which is highly expressed in the spleen, thymus, prostate, testes, ovaries, small intestine, colon and peripheral leukocytes. ARID1A is involved in transcriptional activation and repression of select genes by chromatin remodelling (by altering DNA-nucleosome topology). It is also involved in vitamin D-coupled transcription regulation by associating with the WINAC complex, a chromatin-remodelling complex recruited by vitamin D receptor.

ARID1A belongs to the neural progenitors-specific chromatin remodelling (npBAF) and the neuron-specific chromatin remodelling (nBAF) complexes, which are involved in switching developing neurons from stem/progenitors to post-mitotic chromatin remodelling as they exit the cell cycle and become committed to their adult state.

Molecular pathology
Defects in ARID1A cause mental retardation autosomal dominant type 14.
References in periodicals archive ?
A domestic corporation, A, forms a foreign corporation, E A, which is held by a group of individuals, subsequently transfers several foreign subsidiaries to F in exchange for F stock.
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Olsen, the Supreme Court of Tennessee held that capital gains realized when a corporation liquidated four subsidiary corporations were nonbusiness income.
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iii) Real property that does not give rise to rental of similar income, to the extent used or held for use in the controlled foreign corporation's trade or business; (iv) Intangible property (as defined in section 936(h)(3)(B)), goodwill of going concern value, to the extent used or held for use in the controlled foreign corporation's trade of business.
Should the banks' capital decline, the Board could take action to preserve the safety and soundness of the subsidiary insured depository institutions, including requiring divestiture by the parent holding company of shares already held.
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