Heinz body anaemia

A form of non-spherocytic haemolytic anaemia of Dacie type 1 (OMIM:140700), characterised by an increase of basophilic inclusions—Heinz bodies—which correspond to precipitated haemoglobin within red cells after splenectomy.

Molecular pathology
Defects in HBB, which encodes beta haemoglobin, cause Heinz body anaemia.

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Pencil cells Iron deficiency Stomatocytes Artifact (due to slow drying in humid environment), Liver disease, alcoholism, Rh-null disease, Obstructive lung disease Elliptocytes Hereditary Elliptocytosis (>25%) Bite cells (degmacytes) G6PD deficiency, Oxidative stress, unstable haemoglobins, congenital heinz body anaemia Basket cells (half ghost Oxidant damage, G6PD deficiency, cells/Blister cells) Unstable haemoglobins Spherocytes Hereditary spherocytosis, ABO incompatibility, Autoimmune hemolytic anemia (warm antibody type), Severe burns Teardrop red cell Idiopathic myelofibrosis, (dacrocytes, myelophthisic anaemia, lacrymocytes) thalassemias