heat-shock proteins

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Related to Heat-shock protein: heat shock response, Hsp90

heat-shock proteins

A range of peptides that are well conserved throughout a wide range of organisms and are produced by the body in response to various stressors. They are found in high concentration in plaques of ATHEROSCLEROSIS and levels of heat-shock proteins in people who have suffered strokes and heart attacks, and women with breast cancer, are higher than in controls. Antibodies against bacterial HSP can cross-react with human HSP60 causing cytotoxic damage to endothelial cells stressed by FREE RADICALS or infection. Heat-shock proteins are also associated with oral ulcers and Behçet's disease. They are found in a variety of bacteria.
References in periodicals archive ?
Association of serum antibodies to heat-shock protein 65 with coronary calcification levels: suggestion of pathogen-triggered autoimmunity in early atherosclerosis.
Gene expression of heat-shock proteins (Hsp23, Hsp70 and Hsp90) during and after larval diapause in the blow fly Lucilia sericata.
Small heat-shock proteins (sHSPs) represent an abundant and ubiquitous family of molecular chaperones.
Because the amino acid sequence of the heat-shock protein and the amino acid sequence of the promotor region are highly conservative (153, we propose that the intrauterine device might have induced the expression of hsp60, which became the source of antigenic stimulation for an autopathologic immune response.
Elias and her colleagues also found that giving extra copies of a heat-shock protein 60 fragment called p277 to mice with diabetes symptoms spares beta cells from the immune on-slaught.
Candido's team had engineered strains of the nematode to reveal production of the heat-shock protein, for instance, by fluorescing.
Researchers in the laboratory will also be able to expose tissue cultures with and without the mutated gene to hot temperatures and stress to determine whether torsinA behaves like a heat-shock protein.
Although heat-shock proteins act as protective chaperones," Dr.
Classes of drugs examined include SERMs and SERDs, aromatase inhibitors, microtubule binding agents, HER family inhibitors, angiogenesis inhibitors, miotic inhibitors, vaccines and immunomodulators, cyclooxygenase-2 inhibitors, and inhibitors of heat-shock proteins 90 and 27.
Microbial cells in which heat-shock proteins are synthesized acquire additional tolerance to a second heat challenge that would normally be lethal to them.