HSPB1

(redirected from Heat shock 27 kDa protein)

HSPB1

A gene on chromosome 7q11.23 that encodes a member of the (small) heat shock protein 20 family which is induced by environmental stress. HSPB1 plays a role in stress resistance and actin organisation; it translocates from the cytoplasm to the nucleus in response to stress. It associates with alpha- and beta-tubulin, microtubules and CRYAB, and interacts with HSPB8 and HSPBAP1.

Molecular pathology
Defects of HSPB1 cause Charcot-Marie-Tooth disease type 2F and distal hereditary motor neuropathy 2B.
References in periodicals archive ?
SC Cell Annexin A6 (ANXA 6) Low in SC/High in OM processes Annexin A5 (ANXA 5) -- Annexin A4 (ANXA 4) -- Heat shock Heat shock 27 kDa protein 1 Low in SC /High in OM /chaperone (HSPB 1) Heat shock 70 kDa protein 9 -- (HSPA 9) Heat shock 70 kDa protein 5 -- (HSPA 5) Redox Peroxiredoxin 6 (PRDX 6) Low in OM/High in SC Peroxiredoxin 4 (PRDX 4) -- Peroxiredoxin 1 (PRDX 1) -- Cytoskeleton Actin, beta (ACTB) -- Cofilin 1 [non-muscle] (CFL 1) -- Transgelin (TAGLN) Low in SC/High in OM Caldesmon 1 (CALD 1) ND in SC Gelsolin (GSN) Low in OM/High in SC Metabolism Lactate dehydrogenase B (LDHB) -- Aldehyde dehydrogenase 1 Low in SC/High in OM (ALDH1A 1) Function Name protein OM vs.