Common Hb traits such as Hb AS
and Hb AC, however, do not interfere with the CE-HPLC Hb [A.
An increase in the frequency of Hb monitoring during an acute event can help highlight a trend of increasing Hb as
the underlying condition is resolved, thereby allowing a timely decrease in the Epoetin alfa dose to ensure that Hb levels do not exceed 12 g/dL.
1c] and is characterized by the reversible binding of glucose to Hb as
a Schiff base (1).
Thus, ongoing or periodic use of Hct to assess anemia outcomes may lead to inconsistent and inaccurate results; the NKFK/DOQI[TM] guidelines recommend using Hb as
the primary means of quantifying the level of anemia in patients with ESRD (National Kidney Foundation, 2001).
n) Hb AS
, Hb SS, Hb SC, Hb S/ [beta]-thal, Hb SE, Hb SG-Philadelphia, Hb SO-Arab, Hb SJ-Toronto, and Hb SFukuyama included.
Thus, ongoing or periodic use of Hct to assess anemia outcomes may lead to inconsistent and inaccurate results; the NKF K/DOQI[TM] guidelines recommend using Hb as
the primary means of quantifying the level of anemia in patients with ESRD (NKF-K/DOQI, 200l).
No clinically significant interference attributable to Hb AC or Hb AS
was seen with the Nycocard, Synchron CX7, VARIANT GHb, and VARIANT II methods (Table 1).
A subset of samples with Hb AS (n = 10) was analyzed by Diamat HPLC using two different column series (P and R); all other samples were analyzed using a
Our data for Hb AS samples with the Diamat method were not consistent with previous results (5, 6).
Recently, the effects of Hb AC and Hb AS on one gHb immunoassay method were assessed (5).
The mean percentage of the Hb 5 in samples with Hb AS was 38% (range, 25-41%), and the mean percentage of Hb C in samples with Hb AC was 38% (range, 29-41%).
2 summarizes the most important data, namely, the total concentration of Hb as
a measure of the severity of the disease and the concentration of Hb F.