Hashimoto encephalopathy (HE) is a steroid-responsive, acute or subacute encephalopathy, characterised by autoimmune thyroiditis associated with elevated levels of antithyroid antibodies (1).
Hashimoto encephalopathy usually affects adults with a female-to-male ratio of 4:1.
Hashimoto encephalopathy should be considered in the differential diagnosis of encephalopathy, when infectious, neoplastic, autoimmune, toxic and metabolic causes are excluded.
Hashimoto Encephalopathy (HE) or Steroid-Responsive Encephalopathy associated with Autoimmune Thyroiditis (SREAT) is a rare autoimmune disease characterized by encephalopathy and elevated anti-thyroid antibodies in the absence of a central nervous system (CNS) infection, tumour or stroke.
Once the diagnosis of Hashimoto Encephalopathy (HE) was suspected based on the positive antibody results, all these patients were also given methylprednisolone 1g/day for 5 days with a plan to taper off steroids gradually.
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And "if evidence to support a diagnosis of viral encephalitis, paraneoplastic disorder, depression, peripheral vertigo, Alzheimer's disease, stroke, dementia (nonspecified), CNS vasculitis, peripheral neuropathy, or Hashimoto encephalopathy
is lacking, then the clinician should think about requesting an MRI with diffusion-weighted imaging/apparent diffusion coefficient sequences to look for changes associated with sporadic CJD," they suggested.
presenting as schizophrenia-like disorder.
Kuriyama, "Hashimoto encephalopathy
presenting with progressive cerebellar ataxia," BMJ Case Reports, 2009.