The review highlights the need for randomised placebo-controlled trials to evaluate the effects of selenium in people with Hashimoto disease. Studies also indicate that the effect of selenium depends on the genetic background and the baseline level of selenium in the serum.
Hashimoto disease 50.776 [+ or -] 14.72 64.998 [+ or -] 16.93 (20) (123-86%) [P.sub.1/2A]<0.00003 * [P.sub.1/2B]<0.004 * 3.
Hashimoto disease is observed with a rate of 10% and type 2 DM is observed with a rate of 70% as a component of type 1 autoimmune polyglandular syndrome (OPS).
The frequency of Hashimoto disease is increased in some chromosomal diseases.
Genetic predisposition and familial history with a rate up to 40% have been found in Hashimoto disease (1,2).
Autoimmune thyroiditis, Hashimoto disease, can be diagnosed based on elevated anti-TPO and anti-TG antibodies concentration in patients with hypothyroidism and distinctive ultrasonographic imaging.
The 32-year-old woman has been treated ambulatorically since 2008 for autoimmune thyroiditis, Hashimoto disease. Based on anamnesis and physical examinations, the level of serum thyroid hormones, elevated anti-TPO antibodies concentration, distinctive ultrasonographic imaging and aspiration biopsy, autoimmune thyroiditis was diagnosed.
Hashimoto disease commonly links with autoimmunological diseases, such as: rheumatoid arthritis; Sjogren syndrome; psoriasis; celiakia; and multiglandular autoimmunological syndromes.
In the final step, we compared the two assays with regard to their performance in samples from 87 patients with various autoimmune diseases (rheumatoid arthritis, type I diabetes, Graves disease, Hashimoto disease, and thyroid autoantibodies without hypothyroidism) or known presence of heterophile and human anti-mouse antibodies (HAMAs).
All samples [24 with HAMAs, 25 with heterophilic antibodies, 5 from patients with diabetes, 5 from patients with Graves disease, and 14 from patients with other thyroid disorders (5 from patients with Hashimoto disease, 5 containing thyroid autoantibodies, and 4 from patients with hyperthyroidism of unspecified cause)] were negative in both methods tested.
Another problem is a thyroid ultrasound report that describes the typical features of Hashimoto thyroiditis--coarse texture of the parenchyma and multiple focal 1-6 mm hypoechoic areas (15)--with no mention of Hashimoto disease
as the most likely diagnosis, but with a summary stating only that any one of the focal changes might be a cancer.