Hardy-Weinberg equilibrium

Har·dy-Wein·berg e·qui·lib·ri·um

(har'dē wīn'bĕrg),
that state in which the genetic structure of the population conforms to the prediction of the Hardy-Weinberg law; it is not a stable equilibrium, although for a large mating population it may be approximated.
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Godfrey H., English mathematician, 1877-1947.
Hardy-Weinberg equilibrium - the state in which the genetic structure of the population conforms to the prediction of the Hardy-Weinberg law. Synonym(s): random mating equilibrium
Hardy-Weinberg law - if mating occurs at random with respect to any one autosomal locus in a population in which the gene frequencies are equal in the two sexes, and the factors tending to change gene frequencies are absent or negligible, then in one generation the probabilities of all possible genotypes will on average equal the same proportions as if the genes were assembled at random.


Wilhelm, German physician, 1862-1937.
Hardy-Weinberg equilibrium - see under Hardy, Godfrey H
Hardy-Weinberg law - see under Hardy, Godfrey H
Medical Eponyms © Farlex 2012
References in periodicals archive ?
GENEPOP 4.2 (Raymond and Rousset, 1995) was employed to estimate Potential deviation from Hardy-Weinberg equilibrium (HWE).
The genotype distribution for each polymorphism was evaluated for Hardy-Weinberg equilibrium. The strength of the association between MTHFR gene polymorphisms and CHD was evaluated using the I2 test and odds ratios (OR) with 95% confidence intervals (CI).
A I2 test was used to compare the allele frequency and genotype distribution of each variant following Hardy-Weinberg equilibrium. Unpaired t-test was used to compare between two physical parameters.
If sub-populations are bred as closed flocks in isolation from each other, as is the case in the present study, a deviation from Hardy-Weinberg equilibrium is an expected consequence.
A Chi-square ([chi square]) test was applied to verify whether all subjects were compatible with the Hardy-Weinberg equilibrium (HWE).
Number of alleles (Na), effective number of alleles (Ne), observed heterozygosity (Ho), expected heterozygosity (He), and the Hardy-Weinberg equilibrium test (HW) were calculated for each locus by the GenAlex software version 6.5 (PEAKALL & SMoUSE, 2012).
Statistical analysis: Hardy-Weinberg equilibrium analyses were performed using Hardy-Weinberg equilibrium calculator in www.oege.org/software/Hardy-Weinberg (22).
Although for many years the importance of using specific STR for human identification, forensic DNA casework, missing persons, mass disasters, monitoring needle sharing, monitoring transplants, military casualties and so on has been accepted, for detection of their impact for each population, their forensic parameters specially Hardy-Weinberg equilibrium should be calculated (4).
Both authors suggested that these alleles could explain the deviations from the Hardy-Weinberg equilibrium at the loci where they are present.
Chi-square test was used to check for deviation of genotype distribution from the Hardy-Weinberg equilibrium in both groups.