haptoglobin

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haptoglobin

 [hap´to-glo″bin]
a group of serum alpha2-globulin glycoproteins that bind free hemoglobin; three phenotypes, with differing abilities to bind hemoglobin, are distinguished electrophoretically.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

hap·to·glo·bin (HP),

(hap'tō-glō'bin), [MIM*140100 & MIM*140210]
A group of α2-globulins in human serum, so called because of their ability to combine with hemoglobin, preventing loss in the urine; variant types form a polymorphic system, with α- and β-polypeptide chains controlled by separate genetic loci. Levels are decreased in hemolytic disorders and increased in inflammatory conditions or with tissue damage.
[G. haptō, to grasp, + hemoglobin]
Farlex Partner Medical Dictionary © Farlex 2012

haptoglobin

(hăp′tə-glō′bĭn)
n.
A plasma protein that is a normal constituent of blood serum and functions in the binding of free hemoglobin in the bloodstream.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

haptoglobin

A protein in the circulation that migrates in the α2 portion of serum subjected to electrophoresis, a so-called acute phase reactant that ↑ in serum in acute inflammation or infection, stress, or necrosis Role Bind Hb released from RBCs undergoing hemolysis, preventing the accumulation of Hb in plasma; after iron has been removed, the haptoglobin-bound Hb is eliminated by the reticuloendothelial system.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

hap·to·glo·bin

(hap'tō-glō'bin)
A group of α2-globulins in human serum, so called because of their ability to combine with hemoglobin; variant types form a polymorphic system, with α- and β-polypeptide chains controlled by separate genetic loci.
[G. haptō, to grasp, + hemoglobin]
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

haptoglobin

Alpha2 -globulin, a plasma protein that binds free haemoglobin to form a complex too large to pass out of the kidneys into the urine.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

Haptoglobin

A blood protein made by the liver. Its main role is to save iron by attaching itself to any hemoglobin released from a red cell.
Gale Encyclopedia of Medicine. Copyright 2008 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
Levy, "In vivo and in vitro studies establishing haptoglobin as a major susceptibility gene for diabetic vascular disease," Vascular Health and Risk Management, vol.
Olga et al., "Does haptoglobin genotype affect early onset of diabetic retinopathy in patients with type 2 diabetes?" Retina, vol.
Levy, "Haptoglobin and the development of cerebral artery vasospasm after subarachnoid hemorrhage," Neurology, vol.
Neal et al., "Haptoglobin phenotype predicts the development of focal and global cerebral vasospasm and may influence outcomes after aneurysmal subarachnoid hemorrhage," Proceedings of the National Academy of Sciences of the United States of America, vol.
Our results are consistent with two studies conducted in Brazil, the first of which determined the frequency of the haptoglobin phenotypes in chagasic patients and healthy individuals, presenting the Hp2-2 phenotype (with a lower antioxidant capacity and increased inflammatory reactivity) with an increased frequency in patients compared to healthy individuals [8].
In this study we have highlighted some of the more important aspects of the haptoglobin gene polymorphism and its implications in the T.
De Buyzere, "Fast determination of haptoglobin phenotype and calculation of hemoglobin binding capacity using high pressure gel permeation chromatography," Clinica Chimica Acta, vol.
Worwood, "Haptoglobin: a review of the major allele frequencies worldwide and their association with diseases," International Journal of Laboratory Hematology, vol.
Serum vitamin C concentration is influenced by haptoglobin polymorphism and iron status in Chinese.
If hemoglobin (or its iron) is involved in the etiology of seizures, then inadequate removal of hemoglobin (by haptoglobin) may be important.
NCBI_ID Name of proteins 1 1062 gi|296486435 TPA: vitamin D-binding protein precursor (Bos taurus) 2 630 gi|262050656 complement C4 precursor (Bos taurus) 3 1082 gi|86826758 Paraoxonase 1 (Bos taurus) 4 483 gi|157743038 A2M protein (Bos taurus) 5 616 gi|157743038 A2M protein (Bos taurus) 6 181 gi|28077107 endopin 1 (Bos taurus) 7 805 gi|28077107 endopin 1 (Bos taurus) 8 1083 gi|296480272 TPA: apolipoprotein A-IV precursor (Bos Taurus) 9 1131 gi|296480272 TPA: apolipoprotein A-IV precursor (Bos taurus) 10 1081 gi|42 alpha-1-antitrypsin (Bos taurus) 11 1087 gi|42 alpha-1-antitrypsin (Bos taurus) 12 1318 gi|83638561 Haptoglobin (Bos taurus) 13 1357 gi|83638561 Haptoglobin (Bos taurus) No.
All of these patients had persistent low haptoglobin levels (<0.3 g/L) on day 30, and 2 patients still had LDH levels above the age-dependent upper reference level on day 30.