hapten

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Related to Haptens: Epitopes

hapten

 [hap´ten]
a small molecule, not antigenic by itself, that can react with specific antibodies and elicit the formation of such antibodies when conjugated to a larger antigenic molecule, usually a protein, called in this context the carrier. Antibody production involves activation of B lymphocytes by the hapten and helper T cells by the carrier.

hap·ten

(hap'-ten),
A molecule that is incapable, by itself, of causing a cell-mediated or humoral immune response but can, however, combine with a larger antigenic molecule called a carrier. A hapten-carrier complex can stimulate antibody production and reactive T-cells.
See also: hapten inhibition of precipitation.
[G. haptō, to fasten, bind]

hapten

(hăp′tĕn′) also

haptene

(-tēn′)
n.
A small molecule that reacts with a specific antibody but cannot induce the formation of antibodies unless bound to a carrier protein or other large antigenic molecule.

hap·ten′ic adj.

hap·ten

(hap'tĕn)
A molecule that is incapable, alone, of causing the production of antibodies but can, however, combine with a larger antigenic molecule called a carrier.
Synonym(s): incomplete antigen, partial antigen.
[G. haptō, to fasten, + -en, noun suffix]

hapten

An incomplete antigen that cannot, by itself, promote antibody formation but that can do so when conjugated to a protein. Most haptens are organic substances of low molecular weight. From the Greek haptein , to fasten.

hapten

a substance that is able to combine with specific antibodies but does not produce them unless attached to a large CARRIER MOLECULE.

hap·ten

(hap'tĕn)
A molecule that is incapable, alone, of causing the production of antibodies but can, however, combine with a larger antigenic molecule called a carrier.
Synonym(s): incomplete antigen, partial antigen.
[G. haptō, to fasten, + -en, noun suffix]
References in periodicals archive ?
During the next contact with the same hapten, in the dermis, the antigen-presenting cells (APCs) present the neoantigen to the memory CD8+ lymphocytes, which develop the effector cytotoxic T lymphocyte (CTL) function.
The Montanide[TM] ISA 61 VG adjuvant is specially developed for studying low-immunogenicity antigens in the form of water-inoil (23, 24), which makes it a candidate for working with haptens (Figure 2).
These findings showed that the priming of naive T cells to PPD failed, suggesting that an essential individual susceptibility factor may have been missing from the in vitro T cell priming assay or that PPD did not react to form a hapten.
Particular example of hapten molecules is the ones comprising histamine-succinyl-glycine (HSG) motif and chelate moiety [251-253, 258] for the complexation with [sup.68]Ga.
Studies of chemical selectivity of hapten, reactivity, and skin sensitization potency.
DA is a characteristic hapten with a low molar mass of 311 g/mol, and it cannot induce immune response in animal.
The vaccine "cocktail," as Janda calls it, has three components: a large protein that carries the druglike molecules into the body; a molecule called a hapten, chemically designed to induce an immune response to heroin and its metabolites 6-AM and morphine; and finally, alum, an agent commonly added to vaccines to stimulate release of cytokines, proteins that help rally the immune cells to fight invaders.
LCs have long been assumed to be the DCs responsible for inducing Th1/Tc1 cells in CHS, because of their abundance in the skin, the easy accessibility to haptens, and the strong antigen-presentation ability in vitro.
Once haptens or allergens enter the epithelia, DCs react to these antigens and stimulate the acquired immune response.
Until now, haptens have been measurable only by use of competitive immunoassays because their limited molecular sizes impede simultaneous binding of 2 antibodies to 1 hapten molecule.
It is also possible that methamphetamines alter self-proteins, making them immunogenic or creating haptens. However, these explanations are highly speculative.
Filaggrin deficiency confers a paracellular barrier abnormality that reduces nflammatory thresholds to irritants and haptens. J Allergy Clin Immunol 124(3):496-506.e6 (2009); http://dx.doi.