Furthermore, a European HapMap
Cohort study reported that rs3128917 G and rs9380343 T allele distributions were seen in 25% and 6% for CEU in a healthy population.
LD was estimated by LocusZoom  on the basis of CEU (Utah residents of Northern and Western European ancestry) HapMap
Minor allele frequency of all the polymorphisms was consistent with that reported in the HapMap
ncbi.nlm.nih.gov/sites/entrez?db=Snp) with a frequency over 5% were selected, and tagging SNPs were searched in the HapMap
Coordinate ranges for all HapMap
2 (Build 36) SNPs were converted to Build 37 using liftOver (Kuhn et al.
We report an integrated validation strategy using HapMap
samples and samples with specific disease variants for a combined targeted NGS panel for 5 diseases, including early infantile epileptic encephalopathy, craniofacial disorders, RASopathy disorders, hearing loss, and hereditary cancer.
With the completion of the International HapMap
Project and 1000 Genomes Project, about ten millions SNPs of human were annotated, among which more than 3 million are common SNPs.
The International Human Genome Sequencing Project  and the International HapMap
Project  have generated considerable data on genetic variants and candidate genes for many diseases, including cancer.
All genotypes were simulated with the help of a reference dataset from the International HapMap
According to the results from International HapMap
Project (http://hapmap.ncbi.nlm.nih.gov/) the mutation rates of COX-1 gene polymorphisms, except rs3842788, are very low in Han Chinese, even zero in C22T (R8W) and C714A (L237M).
Imputation was conducted by MACH  or IMPUTE  against the HapMap
CEU reference genome (build 36).
Additionally, minor allele frequency (MAF) of these SNPs in the HapMap
CHB (Chinese Han Beijing) population was >5%.