HapMap


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HapMap

(hăp′măp′)
n.
A database of common genetic variants in human beings from various regions of the world, the result of an international project to describe patterns of genetic variation and their relation to various diseases.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

HapMap

(hap'map)
A catalogue of human genetic variables being gathered worldwide to help increase understanding of genetic diseases and disorders.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

HapMap

(hap′map″) [ hap(lotype) map]
A record of the presence of single nucleotide polymorphisms (alleles) on the chromosomes of some individuals but not others. It is used to identify the inheritance of diseases that do not follow simple mendelian genetics.
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
Furthermore, a European HapMap Cohort study reported that rs3128917 G and rs9380343 T allele distributions were seen in 25% and 6% for CEU in a healthy population.
Assessment of HLADP gene rs3128917 and rs9380343 polymorphisms in chronic HBV infection
LD was estimated by LocusZoom [80] on the basis of CEU (Utah residents of Northern and Western European ancestry) HapMap haplotype data.
Meta-Analysis of Genome-Wide Association Studies Identifies Novel Functional CpG-SNPs Associated with Bone Mineral Density at Lumbar Spine
Minor allele frequency of all the polymorphisms was consistent with that reported in the HapMap database.
Involvement of the IL23/Th17 Pathway in the Pathogenesis of Tunisian Pemphigus Foliaceus
ncbi.nlm.nih.gov/sites/entrez?db=Snp) with a frequency over 5% were selected, and tagging SNPs were searched in the HapMap website (http://www.hapmap.org/index.html.
Association between MFN2 gene polymorphisms and the risk and prognosis of acute liver failure: a case-control study in a Chinese population
Coordinate ranges for all HapMap 2 (Build 36) SNPs were converted to Build 37 using liftOver (Kuhn et al.
Genome-wide association study of susceptibility to particulate matter-associated QT prolongation
We report an integrated validation strategy using HapMap samples and samples with specific disease variants for a combined targeted NGS panel for 5 diseases, including early infantile epileptic encephalopathy, craniofacial disorders, RASopathy disorders, hearing loss, and hereditary cancer.
Development and Validation of Targeted Next-Generation Sequencing Panels for Detection of Germline Variants in Inherited Diseases
With the completion of the International HapMap Project and 1000 Genomes Project, about ten millions SNPs of human were annotated, among which more than 3 million are common SNPs.
Identifying the Risky SNP of Osteoporosis with ID3-PEP Decision Tree Algorithm
The International Human Genome Sequencing Project [1] and the International HapMap Project [2] have generated considerable data on genetic variants and candidate genes for many diseases, including cancer.
Combined Genetic Biomarkers Confer Susceptibility to Risk of Urothelial Bladder Carcinoma in a Saudi Population
All genotypes were simulated with the help of a reference dataset from the International HapMap Consortium [37].
Pathway-Based Kernel Boosting for the Analysis of Genome-Wide Association Studies
According to the results from International HapMap Project (http://hapmap.ncbi.nlm.nih.gov/) the mutation rates of COX-1 gene polymorphisms, except rs3842788, are very low in Han Chinese, even zero in C22T (R8W) and C714A (L237M).
rs5911 and rs3842788 Genetic Polymorphism, Blood Stasis Syndrome, and Plasma TXB2 and hs-CRP Levels Are Associated with Aspirin Resistance in Chinese Chronic Stable Angina Patients
Imputation was conducted by MACH [11] or IMPUTE [12] against the HapMap CEU reference genome (build 36).
Integrating Genome-Wide Association and eQTLs Studies Identifies the Genes and Gene Sets Associated with Diabetes
Additionally, minor allele frequency (MAF) of these SNPs in the HapMap CHB (Chinese Han Beijing) population was >5%.
Association between Common Genetic Variants and Polycystic Ovary Syndrome Risk in a Chinese Han Population
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