Hantavirus Infections


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Hantavirus Infections

 

Definition

Hantavirus infection is caused by a group of viruses that can infect humans with two serious illnesses: hemorrhagic fever with renal syndrome (HFRS), and Hantavirus pulmonary syndrome (HPS).

Description

Hantaviruses are found without causing symptoms within various species of rodents and are passed to humans by exposure to the urine, feces, or saliva of those infected rodents. Ten different hantaviruses have been identified as important in humans. Each is found in specific geographic regions, and therefore is spread by different rodent carriers. Further, each type of virus causes a slightly different form of illness in its human hosts:
  • Hantaan virus is carried by the striped field mouse, and exists in Korea, China, Eastern Russia, and the Balkans. Hantaan virus causes a severe form of hemorrhagic fever with renal syndrome (HFRS).
  • Puumula virus is carried by bank voles, and exists in Scandinavia, western Russia, and Europe. Puumula virus causes a milder form of HFRS, usually termed nephropathia epidemica.
  • Seoul virus is carried by a type of rat called the Norway rat, and exists worldwide, but causes disease almost exclusively in Asia. Seoul virus causes a form of HFRS that is slightly milder than that caused by Hantaan virus, but results in liver complications.
  • Prospect Hill virus is carried by meadow voles and exists in the United States, but has not been found to cause human disease.
  • Sin Nombre virus, the most predominant strain in the United States, is carried by the deer mouse. This virus was responsible for severe cases of HPS that occurred in the Southwestern United States in 1993.
  • Black Creek Canal virus has been found in Florida. It is predominantly carried by cotton rats.
  • New York virus strain has been documented in New York State. The vectors for this virus seem to be deer mice and white-footed mice.
  • Bayou virus has been reported in Louisiana and Texas and is carried by the marsh rice rat.
  • Blue River virus has been found in Indiana and Oklahoma and seems to be associated with the white-footed mouse.
  • Monongahela virus, discovered in 2000, has been found in Pennsylvania and is transmitted by the white-footed mouse.

Causes and symptoms

Hemorrhagic fever with renal syndrome (hfrs)

Hantaviruses that produce forms of hemorrhagic fever with renal syndrome (HFRS) cause a classic group of symptoms, including fever, malfunction of the kidneys, and low platelet count. Because platelets are blood cells important in proper clotting, low numbers of circulating platelets can result in spontaneous bleeding, or hemorrhage.
Patients with HFRS have pain in the head, abdomen, and lower back, and may report bloodshot eyes and blurry vision. Tiny pinpoint hemorrhages, called petechiae, may appear on the upper body and the soft palate in the mouth. The patient's face, chest, abdomen, and back often appear flushed and red, as if sunburned.
After about five days, the patient may have a sudden drop in blood pressure; often it drops low enough to cause the clinical syndrome called shock. Shock is a state in which blood circulation throughout the body is insufficient to deliver proper quantities of oxygen. Lengthy shock can result in permanent damage to the body's organs, particularly the brain, which is very sensitive to oxygen deprivation.
Around day eight of HFRS, kidney involvement results in multiple derangements of the body chemistry. Simultaneously, the hemorrhagic features of the illness begin to cause spontaneous bleeding, as demonstrated by bloody urine, bloody vomit, and in very serious cases, brain hemorrhages with resulting changes in consciousness.
Day eleven often brings further chemical derangements, with associated confusion, hallucinations, seizures, and lung complications. Those who survive this final phase usually begin to turn the corner toward recovery at this time, although recovery takes approximately six weeks.

Hantavirus pulmonary syndrome (hps)

Hantavirus pulmonary syndrome (HPS) develops in four stages. They are:
  • The incubation period. This lasts from one to five weeks from exposure. Here, the patient may exhibit no symptoms.
  • The prodrome, or warning signs, stage. Symptoms begin with a fever, muscle aches, headache, dizziness, and abdominal pain and upset. Sometimes there is vomiting and diarrhea.
  • The cardiopulmonary stage. The patient slips into this stage rapidly, sometimes within a day or two of initial symptoms; sometimes as long as 10 days later. There is a drop in blood pressure, shock, and leaking of the blood vessels of the lungs, which results in fluid accumulation in the lungs, and subsequent shortness of breath. The fluid accumulation can be so rapid and so severe as to put the patient in respiratory failure within only a few hours. Some patients experience severe abdominal tenderness.
  • The convalescent stage. If the patient survives the respiratory complications of the previous stage, there is a rapid recovery, usually within a day or two. However, abnormal liver and lung functioning may persist for six months.

Diagnosis

Serologic techniques help diagnose a hantavirus infection. The patient's blood is drawn, and the ELISA (enzyme-linked immunosorbent assay) is done in a laboratory to identify the presence of specific immune substances (antibodies)—substances which an individual's body would only produce in response to the hantavirus.
It is very difficult to demonstrate the actual virus in human tissue, or to grow cultures of the virus within the laboratory, so the majority of diagnostic tests use indirect means to demonstrate the presence of the virus.

Treatment

Treatment of hantavirus infections is primarily supportive, because there are no agents available to kill the viruses and interrupt the infection. Broad-spectrum antibiotics are given until the diagnosis is confirmed. Supportive care consists of providing treatment in response to the patient's symptoms. Because both HFRS and HPS progress so rapidly, patients must be closely monitored, so that treatment may be started at the first sign of a particular problem. Low blood pressure is treated with medications. Blood transfusions are given for both hemorrhage and shock states. Hemodialysis is used in kidney failure. (Hemodialysis involves mechanically cleansing the blood outside of the body, to replace the kidney's normal function of removing various toxins form the blood.) Rapid respiratory assistance is critical, often requiring intubation.
The anti-viral agent ribavirin has been approved for use in early treatment of hantavirus infections.

Prognosis

The diseases caused by hantaviruses are extraordinarily lethal. About 6-15% of people who contract HFRS have died. Almost half of all people who contract HPS will die. This gives HPS one of the highest fatality rates of any acute viral disease. It is essential that people living in areas where the hantaviruses exist seek quick medical treatment should they begin to develop an illness that might be due to a hantavirus.

Prevention

There are no immunizations currently available against any of the hantaviruses. In 2003, developments in genetic science were helping researchers work on a possible vaccination and therapy for several versions of hantavirus, including the Sin Nombre virus that causes HPS. With further work, a gene-based vaccine could become available in the future. However, the only known forms of hantavirus prevention involve rodent control within the community and within individual households. The following is a list of preventive measures:
  • Avoiding areas known to be infested by rodents is essential.
  • Keeping a clean home and keeping food in rodent-proof containers.
  • Disposing of garbage and emptying pet food dishes at night.
  • Setting rodent traps around baseboards and in tight places. Disposing of dead animals with gloves and disinfecting the area with bleach.
  • Using rodenticide as necessary.
  • Sealing any entry holes 0.25 inch wide or wider around foundations with screen, cement, or metal flashing.
  • Clearing brush and junk from house foundations.
  • Putting metal flashing around house foundations.
  • Elevating hay, woodpiles, and refuse containers.
  • Airing out all sealed outbuildings or cabins 30 minutes before cleaning for the season.
  • When camping, avoiding sleeping on the bare ground. It is advised to sleep on a cot or in a tent with a floor.

Resources

Books

Harper, David R., and Andrea S. Meyer. Of Mice, Men, and Microbes: Hantavirus. San Diego: Academic Press, 1999.

Periodicals

"DNA Vaccine Protects Against Hantavirus Pulmonary Syndrome." Heart Disease Weekly November 2, 2003: 31.
Jones, Amy. "Setting a Trap for Hantavirus." Nursing September 2000: 20.
Monroe, Martha C., Sergey P. Morzunov, Angela M. Johnson, Michael De. Bowen, et al. "Genetic Diversity and Distribution of Peromyscus-Borne Hantaviruses in North America." Nursing January-February 1999: 75-86.
Naughton, Laurie. "Hantavirus Infection in the United States: Are We Prepared?" Physician Assistant May 2000: 33.
Rhodes III, Luther V., Cinnia Huang, Angela J. Sanchez, Stuart T. Nichol, et al. "Hantavirus Pulmonary Syndrome Associated with Monongahela Virus, Pennsylvania." Emerging Infectious Diseases November 2000: 616.
Van Bevern, Pamela A. "Hantavirus Pulmonary Syndrome." Clinician Reviews July 2000: 108.

Key terms

Hemodialysis — A method of mechanically cleansing the blood outside of the body, in order to remove various substances that would normally be cleared by the kidneys. Hemodialysis is used when an individual is in relative, or complete, kidney failure.
Hemorrhagic — A condition resulting in massive, difficult-to-control bleeding.
Petechiae — Pinpoint size red spots caused by hemorrhaging under the skin.
Platelets — Circulating blood cells that are crucial to the mechanism of clotting.
Prodrome — Early symptoms or warning signs
Pulmonary — Referring to the lungs.
Renal — Referring to the kidneys.
Shock — Shock is a state in which blood circulation is insufficient to deliver adequate oxygen to vital organs.
References in periodicals archive ?
For this grant, Ichor aims to build on its success and develop broadly neutralizing Abs against all hantavirus infections.
Hantavirus infections are considered to be rare, but factors such as climate change and urbanisation are expected to increase the incidence of infections in the future.
We think that hantavirus infections deserve to be on that list.
Herewith, six years before the description of Sin Nombre virus- (SNV-) induced HPS as a newly recognized disease in Southwestern USA [4], a very similar entity of acute noncardiogenic lung edema, during a hantavirus infection in a previously healthy young adult, was already reported from Europe.
Rodent control in and around the home remains the primary strategy for preventing hantavirus infection. From the public health point of view, the recommended measures that need to be used in concert are: (1) prevent rodents from entering the home by repairing gaps inside and outside the house, (2) trap rodents around the home to help reduce the population, (3) clean up rodent food sources and nesting sites, and (4) take precautions when cleaning rodent-infested areas.
Clinical diagnosis of hantavirus infection has been routinely confirmed by Western blot assays, hemagglutination inhibition assays, immunofluorescence antibody assay, or ELISA with native viral antigens.
The size of the lipid perturbations correlates with the severity of the underlying hantavirus infection. And because the lipid changes precede by several days, the deterioration in renal function and worsening thrombocytopenia that mark a serious hantavirus infection, the extent of the lipid abnormalities can be used as an early warning system regarding the viral illness to come, according to Dr.
M2 PHARMA-May 13, 2019-Ichor Biologics announces receipt of USD300,000 grant from NIH for development of therapeutic antibodies against hantavirus infections
These reports might bring to an end the long-maintained concept that human hantavirus infections were to be distinguished between HFRS in the Old World and hantavirus cardiopulmonary syndrome (HCPS) in the New World (1).
Human hantavirus infections are nationally notifiable in the United States and suspected cases should be reported to state or local health departments.