halofantrine


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halofantrine

 [-fan´trēn]
an antimalarial agent used as the hydrochloride salt in treatment of acute malaria due to Plasmodium falciparum or P. vivax.

halofantrine

A phenanthrene anti-malarial drug used to treat both main types of malaria, those caused by Plasmodium falciparum and Plasmodium vivax . A brand name is Halfan.
References in periodicals archive ?
Likewise, it has been shown that artemisinins, artemether-lumefantrine and halofantrine abnormally increase production of liver enzymes in animal models (Obi et al., 2004; Adaramoye et al., 2008).
Mutations (N86Y, Y184F, S1034C, N1042D, and D1246Y) in the pfmdr1 gene have been associated with resistance to multiple antimalarial drugs such as quinine, mefloquine, halofantrine, artemisinin, lumefantrine, CQ, and amodiaquine [10-13].
falciparum to 4-aminoquinolines (chloroquine, amodiaquine), antifols, and dihydrofolate reductase inhibitors (pyrimethamine, proguanil) in many endemic regions [6] and the emergence of in vitro and in vivo resistance to aminoalcohols (quinine, mefloquine, and halofantrine) have been reported in some areas of Southeast Asia [7-9].
Decreasingpfmdr1 copy number in Plasmodium falciparum malaria heightens susceptibility to mefloquine, lumefantrine, halofantrine, quinine, and artemisinin.
Intestinal lymphatic transport of halofantrine in rats assessed using a chylomicron flow blocking approach: the influence of polysorbate 60 and 80.
Charman, "Intestinal lymphatic transport of halofantrine occurs after oral administration of a unit-dose lipid-based formulation to fasted dogs," Pharmaceutical Research, vol.
For clinical studies, new high performance liquid chromatographic (HPLC) methods were developed for the analysis of antimalarial drugs such as quinine, (17) halofantrine, (18) mefloquine-sulfadoxine-pyrimethamine, (19) and ciprofloxacin.
Nnadi, "Development and validation of novel hydrotropic solubilization method for spectrophotometric determination of halofantrine in pure and solid dosage form," Scholar's Academic Journal of Pharmacy, vol.
Charman, "Formulation design and bioavailability assessment of lipidic self-emulsifying formulations of halofantrine," International Journal of Pharmaceutics, vol.
Balogun, "Some serum and tissue enzyme changes in mice infected with Plasmodium yoelii nigeriensis before and after administration of halofantrine hydrochloride," Nigerian Journal of Biochemistry and Molecular Biology, vol.
Halofantrine metabolism in microsomes in man: major role of CYP 3A4 and CYP 3A5.