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trademark for a preparation of haloperidol, an antipsychotic agent.


Apo-Haloperidol (CA), Dozic (UK), Novo-Peridol (CA), Peridol (CA), PMS Haloperidol (CA), Serenace (UK)

haloperidol decanoate

Haldol Decanoate 50, Haloperidol LA Omega (CA)

haloperidol lactate


Pharmacologic class: Butyrophenone

Therapeutic class: Antipsychotic

Pregnancy risk category C

FDA Box Warning

• Drug increased mortality in elderly patients with dementia-related psychosis. Although causes of death were varied, most appeared to be cardiovascular or infectious. Drug isn't approved for treatment of dementia-related psychosis.


Unknown. Thought to block postsynaptic dopamine receptors in brain and increase dopamine turnover rate, inhibiting signs and symptoms of psychosis.


Injection (decanoate): 50 mg/ml, 100 mg/ml

Injection (lactate): 5 mg/ml

Oral concentrate (lactate): 2 mg/ml

Tablets: 0.5 mg, 1 mg, 2 mg, 5 mg, 10 mg, 20 mg

Indications and dosages

Symptomatic treatment of psychotic disorders or Tourette syndrome

Adults: For moderate symptoms, 0.5 to 2 mg P.O. two to three times daily. For severe symptoms or chronic or resistant disorder, 3 to 5 mg P.O. two to three times daily, to a maximum of 100 mg daily if needed. Adjust subsequent dosages carefully based on response and tolerance. Alternatively, 2 to 5 mg I.M. (lactate) may be given for prompt control of acutely agitated patient with moderate to severe symptoms; based on response, subsequent doses may be given q hour.

Schizophrenia in patients who need prolonged parenteral antipsychotic therapy

Adults: For patient previously stabilized on oral haloperidol, initial I.M. dose (decanoate) is 10 to 20 times the previous daily P.O. haloperidol equivalent, depending on patient's stability on low or high P.O. dosage. Initially, I.M. dosage shouldn't exceed 100 mg. If conversion requires dosage above 100 mg, give balance in 3 to 7 days. Maintenance dosage is 10 to 15 times the previous daily P.O. dosage, depending on response.

Psychotic disorders

Children ages 3 to 12 or weighing 15 to 40 kg (33 to 88 lb): 0.05 to 0.15 mg/kg/day P.O. in two or three divided doses. May be increased by 0.5 mg daily given in two or three divided doses at 5- to 7-day intervals, depending on response and tolerance.

Nonpsychotic behavior disorder; Tourette syndrome; hyperactivity

Children ages 3 to 12 or weighing 15 to 40 kg (33 to 88 lb): 0.05 to 0.075 mg/kg/day P.O. in two or three divided doses

Dosage adjustment

• Elderly or debilitated patients

Off-label uses

• Nausea and vomiting

• Infantile autism

• Intractable hiccups


• Hypersensitivity to drug, tartrazine, sesame oil, or benzyl alcohol (with some products)

• Severe CNS depression or comatose states

• Parkinson's disease


Use cautiously in:

• torsades de pointes, QT interval prolongation

• patients with allergies

• hepatic disease, bone marrow depression, cardiac disease, respiratory insufficiency, CNS tumors

• history of seizures, patients receiving anticonvulsants, EEG abnormalities

• concurrent anticoagulant use

• elderly patients

• pregnant or breastfeeding patients

• children (parenteral form not recommended).


• Be aware that torsades de pointes and QT interval prolongation have occurred in patients receiving haloperidol, especially when drug is given I.V. or in doses higher than recommended. Haloperidol isn't approved for I.V. use.

Don't give decanoate form I.V.

• Administer decanoate form by deep I.M. injection using 21G needle. Two injections may be necessary; maximum volume shouldn't exceed 3 ml.

• Know that recommended interval between I.M. injections is 4 weeks.

• Dilute oral concentrate in water, soda, or juice (orange, apple, tomato) immediately before administering.

• Be aware that patient should be switched from parenteral form to oral form as soon as possible.

• Know that parenteral form is not recommended in children.

Adverse reactions

CNS: confusion, drowsiness, restlessness, extrapyramidal reactions, sedation, lethargy, insomnia, vertigo, tardive dyskinesia, seizures, neuroleptic malignant syndrome

CV: hypotension, hypertension, tachycardia, ECG changes, torsades de pointes (with I.V. use)

EENT: blurred vision, dry eyes

GI: constipation, ileus, dry mouth, anorexia

GU: urinary retention, menstrual irregularities, gynecomastia, priapism

Hematologic: anemia, leukocytosis, leukopenia

Hepatic: jaundice, drug-induced hepatitis

Metabolic: galactorrhea

Respiratory: dyspnea, respiratory depression, bronchospasm, laryngospasm

Skin: diaphoresis, photosensitivity, rash

Other: hyperpyrexia, hypersensitivity reactions


Drug-drug. Antidepressants, antihistamines, atropine, disopyramide, phenothiazines, quinidine, other anticholinergics: additive anticholinergic effects

Antihypertensives, nitrates: additive hypotension

CNS depressants (including antihistamines, opioid analgesics, sedative-hypnotics): additive CNS depression

Epinephrine: severe hypotension and tachycardia

Levodopa, pergolide: decreased therapeutic effects of haloperidol

Lithium: acute encephalopathic syndrome

Methyldopa: dementia

Rifampin: decreased haloperidol plasma level

Drug-diagnostic tests. Alanine aminotransferase, aspartate aminotransferase, thyroid function tests: increased values

Arterial blood gases, bicarbonate: altered values

White blood cells: increased or decreased count

Drug-herbs. Angel's trumpet, jimsonweed, scopolia: antagonism of cholinergic effects

Chamomile, hops, kava, skullcap, valerian: increased CNS depression

Nutmeg: reduced haloperidol efficacy

Drug-behaviors. Acute alcohol ingestion: additive hypotension

Patient monitoring

Monitor CNS status closely, especially for seizures and neuroleptic malignant syndrome (shown by extrapyramidal symptoms, hyperthermia, and autonomic disturbances).

Monitor cardiovascular status, particularly for ECG changes, blood pressure changes, torsades de pointes, and atypical rapid ventricular tachycardia, which may progress to ventricular fibrillation (with I.V. use).

• Assess respiratory status.

• Monitor liver function test results and CBC with white cell differential.

• With prolonged use, assess for tardive dyskinesia (which may occur months or even years after starting drug).

Patient teaching

• Tell patient to dilute oral concentrate with water, cola, or juice immediately before taking.

Instruct patient to immediately report signs or symptoms of serious adverse reactions, such as unusual weakness, yellowing of skin or eyes, difficulty breathing, or symptoms of neuroleptic malignant syndrome (such as fever, muscle pain or rigidity, rapid or irregular pulse, increased sweating, change in urination pattern, or decreased mental acuity).

• Advise patient to minimize GI upset by eating frequent, small servings of food and drinking adequate fluids.

• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, herbs, and behaviors mentioned above.


(hăl′dôl′, -dŏl′, -dōl′)
A trademark for the drug haloperidol.


Haloperidol, see there.


A brand name for HALOPERIDOL.


A brand name for HALOPERIDOL.
References in periodicals archive ?
MY MEMOIR, The Heart Too Long Suppressed: A Chronicle of Mental Illness, relays the circumstances under which I tossed overboard from the deck of a ship the following medications: the tranquilizers Haldol and Thorazine and the antidepressants Imipramine Daytime and Tofranil-PM.
The only record of note carried from the pre-2004, written medical records is Panetti's allergies to three psychiatric drugs used to treat schizophrenia: Mellaril, Thorazine and Haldol. It is believed that Panetti told TDCJ heath staff of the allergies when he arrived in 1995.
He was assaultive to EMS on transport and on arrival at the ED he was given Haldol 5mg and Ativan 2mg for his agitation.
Eventually, the patient was subdued with a bit of Haldol.
Were he as agitated and distressed as in the police report, I probably would have administered an immediate dose of Haldol, the most powerful fast-acting antipsychotic of the time.
It is omitted from all the photo titles and passages in the book, and Lutz never so much as refers to her as "my mother." It is only by closely scrutinizing the details in one photo--an extreme close-up of an arm in a hospital bed with wristbands that say "Haldol" and "Fall Risk" in large bold lettering--that one can make out the name Jinne Lutz in smaller, faded type on a third bracelet.
Those with weak (30%-50%) inhibitory effects included fluticas-one, voriconazole (Vfend), nifedipine, erythromycin, sertraline (Zoloft), haloperidol (Haldol), and trazodone, and those with negligible (less than 20%) inhibitory effects included midazolam (Versed), quetiapine (Seroquel), venlafaxine (Effexor), citalopram (Celexa), clarithromycin (Biaxin), metronidazole (Flagyl), cyclosporine, sirolimus (Rapamune), and ondansetron (Zofran), said Dr.
He instructed Nurse Brigham to administer the antipsychotic drug, Haldol: lithium, for the bipolar disorder; and Atavan, to calm her impulsive behavior.
For example, Haldol was ordered by a psychiatrist to manage the verbally-abusive behaviour of a patient in a nursing, home.
We had to hold her down and give her an injection of Haldol. We knew next time we needed to intervene earlier and try to redirect.