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Related to Halcion: Halcyon Days


Apo-Triazo (CA), Gen-Triazolam (CA), Halcion

Pharmacologic class: Benzodiazepine

Therapeutic class: Sedative-hypnotic

Controlled substance schedule IV

Pregnancy risk category X


Inhibits gamma-aminobutyric acid, a neurotransmitter that activates receptors at limbic, thalamic, and hypothalamic levels of CNS


Tablets: 0.125 mg, 0.25 mg, 0.5 mg

Indications and dosages


Adults: 0.125 to 0.5 mg P.O. at bedtime p.r.n. After 7 to 10 days, decrease dosage gradually and then discontinue.

Dosage adjustment

• Elderly or debilitated patients

Off-label uses

• Presurgical hypnotic


• Hypersensitivity to drug or other benzodiazepines

• Concurrent use of itraconazole, ketoconazole, or nefazodone

• Pregnancy


Use cautiously in:

• hepatic or renal dysfunction, sleep apnea, respiratory compromise, psychosis

• history of suicide attempt or drug abuse

• elderly or debilitated patients

• breastfeeding patients

• children younger than age 18 (safety and efficacy not established).


• Don't give with grapefruit juice.

Adverse reactions

CNS: dizziness, excessive sedation, hangover, headache, anterograde or traveler's amnesia, confusion, incoordination, lethargy, depression, paradoxical excitation, light-headedness, psychological disturbance, euphoria

GI: nausea, vomiting

Other: physical or psychological drug dependence, drug tolerance, withdrawal symptoms (tremor, abdominal and muscle cramps, vomiting, diaphoresis, dysphoria, perceptual disturbances, insomnia)


Drug-drug. Antidepressants, antihistamines, chloral hydrate, opioid analgesics, other psychotropic drugs: additive CNS depression

Cimetidine, disulfiram, fluconazole, hormonal contraceptives, isoniazid, itraconazole, ketoconazole, nefazodone, rifampin, and other drugs that inhibit CYP450-3A4-mediated metabolism: decreased oxidative metabolism and increased action of triazolam

Digoxin: increased digoxin blood level, greater risk of toxicity

Macrolide anti-infectives (such as azithromycin, clarithromycin, erythromycin): increased triazolam bioavailability

Probenecid: rapid onset and prolonged effects of triazolam

Ranitidine: increased triazolam blood level

Theophylline: decreased sedative effect of triazolam

Drug-food. Grapefruit juice: increased triazolam blood level and effects

Drug-herbs. Chamomile, hops, kava, skullcap, valerian: increased CNS depression

Drug-behaviors. Alcohol use: increased CNS depression

Smoking: increased triazolam clearance

Patient monitoring

• Monitor neurologic status. Watch for paradoxical or rebound drug effects.

• Observe for signs of drug hoarding and drug abuse.

Patient teaching

• Tell patient to take at bedtime with a liquid other than grapefruit juice.

• Explain that drug is meant only for short-term use (7 to 10 days).

• Tell patient rebound insomnia may occur for 1 to 2 nights after he discontinues drug.

• Instruct patient to avoid alcohol use and smoking.

• Caution patient to avoid driving and other hazardous activities while under drug's influence.

• As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs, foods, herbs, and behaviors mentioned above.

McGraw-Hill Nurse's Drug Handbook, 7th Ed. Copyright © 2013 by The McGraw-Hill Companies, Inc. All rights reserved


A trademark for the drug triazolam.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.


Triazolam Pharmacology A hypnotic with serious side effects–eg, paranoia and severe anxiety
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
And yet, even more amazing, a grown man, an educated adult, a full professor, who seeks self-integration!" (55) Philip clearly distinguishes his own quest for an integrated subjectivity independent of the effects of Halcion and of Pipik from Ziad's; what he seeks, ultimately, is a reprieve from those identities that demand such integration.
2619, 2650 (1995) (noting that defective products that were allegedly hidden include "Dow Corning's silicone gel breast implants; pickup trucks made by Ford and General Motors; Upjohn's sleeping pill Halcion ...
(269) Similarly, in response to the publication of the first paper detailing the serious side effects of the sleeping pill Halcion in The Lancet, the pill's manufacturer convened a group of sleep researchers who sent a letter to the journal denouncing the study.
The more sedating benzodiazepines, such as Halcion and ProSom, are prescribed for short-term treatment of sleep disorders.
Often, physicians will prescribe a hypnotic, such as Restoril, Halcion, Ambien or Sonata for short-term use, usually two to three weeks.
711, 712-13, 716, 729-30 (2004) (detailing his own and other judges' admissions that they have approved secret settlements under pressure stemming from an extreme caseload); Luban, supra note 2, at 2650 (concluding that among the two hundred sealed records cases between 1980 and 1987 in Dallas County, one finds several examples of product defects that have affected public safety, including Dow Corning's silicone breast implants, Ford and General Motors pickup trucks, and Upjohn's sleeping pill Halcion); Richard A.
The earlier sleep medication was triazolam, sold as Halcion. It lost best-seller status when researchers realized that at excessive doses, it could cause memory deficits and hallucinations.
Commonly prescribed benzodiazepine sleep-aids are: flurazepam (Dalmane), estazolam (ProSom), temazepam (Restoril) and triazolam (Halcion).
Shapiro-Baruch (1995) described her experiences with a physician who insisted that she take a Halcion over 14 months for complaints of sleeplessness.
One tiny, 0.25 milligram Halcion. That one pill set off a chain reaction that left Dr.
The following drugs have been found to interact with grapefruit juice (to be sure of your medications, ask your pharmacist): calcium channel blockers (for high blood pressure)--felodipine (Plendil), nifedipine (Procardia, Adalat), nisoldipine (Sular); immunosuppressant drugs (for organ transplants)--cyclosporine (Neoral, Sandimmune, SangCya), tacrolimus (Prograf); drugs for anxiety, insomnia or depression--diazepam (Valium), triazolam (Halcion), zaleplon (Sonata), carbamazepine (Tegretol), clomipramine (Anafranil).