There is frequently a degree of cross-over between cytotoxicity and haemotoxicity
in cytotoxic envenomations.
2) Clozapine is widely known to cause bone marrow haemotoxicity
Of the 35 children, 8 had only neurotoxic features, 2 had only haemotoxic features 7 had only local swelling, 14 had neurotoxicity and local swelling, 1 had haemotoxicity
and local swelling, 1 had both haemotoxicity
and neurotoxicity and 2 had neurotoxicity, haemotoxicity
and local swelling.
This is especially important in cases of haemotoxicity
Chloramphenicol is used extensively in non-industrialised countries for life--threatening infections because it is cheap and effective despite its known haemotoxicity
and linkage to fatal aplastic anaemia (Saba et al.
38) is high among the toxicities observed, next comes the pure haemotoxicity (25.
38%) among all the toxicities followed by pure haemotoxicity (25.
The most common complication from snakebites was haemotoxicity
(59%), usually involving a thrombocytopenia which, when significant (defined as platelets <50 x [10.
Regarding the pattern of systemic involvement, 21 patients had predominantly haemotoxic symptoms, 17 had neurotoxic symptoms, 13 patients had both haemotoxicity and neurotoxicity, and 37 patients had cellulitis.
Patients with severe neurotoxicity like respiratory failure and patients with both haemotoxicity and neurotoxicity required 28-30 vials of ASV.
Snakebite envenomation can present mainly as haemotoxicity or neurotoxicity.
Haemotoxicity (prolonged whole blood clotting time/PT/APTT) can present as bleeding manifestations, capillary leak syndrome or disseminated intravascular coagulation (DIC) and acute renal failure.