The Phase 3 trial was a 1:1 randomised, double-blind, placebo-controlled study involving 514 CMV seropositive subjects undergoing
haematopoietic stem cell transplantation.
Chin, "Quality of life after haematopoietic stem cell transplantation in a multiracial population," Medical Journal of Malaysia, vol.
Chang, "Health psychology and distress after haematopoietic stem cell transplantation," European Journal of Cancer Care, vol.
Mark added that due to her constant pain and auto-neural problems, there was no better option but to undergo the
haematopoietic stem cell transplant.
For the Retro Nectin treatment, VM106 utilizes a retro virus vector to inject gp91, the normal treatment gene, into the extracted
haematopoietic stem cell of the patient.
The
haematopoietic stem cells provide replenishment of red blood cells or immune cells, so they can be used for the treatment of leukemia, in a way that the diseased cells of the patient are replaced with healthy
haematopoietic stem cells from a matched donor.
Citation: " M-CSF instructs myeloid lineage fate in single
haematopoietic stem cells"; Noushine MossadeghKeller et al.; Nature, 2013; DOI: 10.1038/nature12026
