PRPF40A

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PRPF40A

A gene on chromosome 2q23.3 that encodes a PRPF40 family protein which binds to WASL, suppressing its translocation from the nucleus to the cytoplasm and inhibiting its activity. PRPF40A plays a role in regulating cell morphology, cytoskeletal organisation and cell migration, and may play a role in cytokinesis and pre-mRNA splicing. It is widely expressed, especially in the cerebral cortex.
References in periodicals archive ?
Su observacion detenida nos da indicios sobre las probables causas: la poblacion Uro tiene las frecuencias de los marcadores HYPA y LYPB invertidas respecto a las de sus vecinas islenas de Puno y acusa en consecuencia un grado importante de miscigenacion.
HYPA LYPB LYQA LYPA LXPA LYQC Chiclayo 0,5217 0,4058 0,0000 0,0435 0,0145 0,0145 Iquitos 0,4875 0,2667 0,0500 0,0000 0,0333 0,0000 Pucallpa 0,5500 0,2250 0,1000 0,0750 0,0500 0,0000 Taquile 0,1964 0,7847 0,0000 0,0179 0,0000 0,0000 Amantani 0,1833 0,8000 0,0000 0,0167 0,0000 0,0000 Uro 0,6346 0,3462 0,0000 0,0192 0,0000 0,0000 Anapia 0,4167 0,5833 0,0000 0,0000 0,0000 0,0000 Tabla 4.
HYPA is financially backed by Hispania and formed by several prominent Hispanic publishers for the purpose of building and operating Spanish-language yellow pages directories across key U.