HUS1

HUS1

A gene on chromosome 7p13-p12 that belongs to an evolutionarily conserved, genotoxin-activated checkpoint complex, which triggers cell-cycle arrest in response to DNA damage. HUS1 forms a heterotrimeric complex with checkpoint proteins RAD9 and RAD1, which then interacts with another protein complex—checkpoint protein RAD17 and 4 small subunits of the replication factor C—loading the complex onto the chromatin. The DNA damage induced-chromatin binding depends on activation of checkpoint kinase ATM, and may be an early checkpoint-signalling event.
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11] APP, COL14A1, ROBO1, ITGAV, COL12A1, SCARB1, SCARB2, CNTN3, MFAP4, COL24A1, THBS2 multicellular 46 AEBP1, S100A6, HUS1, UTRN, 0,005 organismal GPM6B, POSTN, FKBP1A, ENPEP, development MYLIP, CBFB, PTK2, APP, ROBO1, CASP7, ITGAV, COL12A1, FBN2, LOX, USH2A, OLFM1, DCLK1, MLLT3, EGFL6, NRXN3, MAP1B, CHODL, ITGA2, AFF3, IGF2, SIRT1, COL5A1, CTNNBIP1, DKK3, MAN2A1, DACT1, CNTF, TMEM111, SFRP2, GRN, IRF1, SORT1, CNTN3, PSME4, COL1A1, CASQ2, MYH10 muscle organ 8 APP, AEBP1, CNTF, UTRN, CHODL, 0,008 development FKBP1A, SIRT1, MYH10 lipid 9 PTGES3, SAMD8, CYB5R1, AGPAT5, 0,026 biosynthetic C1QTNF3, LASS3, ALOX5AP, process SCARB1, ELOVL6 La interpretacion funcional mostro enriquecimiento en funciones estrechamente relacionadas con el desarrollo y adipogenesis del tejido muscular.