dystransthyretinemic euthyroidal hyperthyroxinaemia

(redirected from HTDE)

dystransthyretinemic euthyroidal hyperthyroxinaemia

A hereditary form of generalised amyloidosis (OMIM:105210) caused by transthyretin (amyloid) deposition, leading to amyloid polyneuropathy, amyloidotic cardiomyopathy, carpal tunnel syndrome, systemic senile amyloidosis and leptomeningeal amyloidosis, with amyloid in the walls of leptomeningeal vessels in pia arachnoid and subpial regions. Some patients also develop vitreous amyloid deposition leading to visual impairment (oculoleptomeningeal amyloidosis).

Clinical features
Seizures, stroke-like episodes, dementia, psychomotor deterioration, variable amyloid deposition in the vitreous humour.

Molecular pathology
Defects of TTR, which encodes transthyretin, cause dystransthyretinemic euthyroidal hyperthyroxinaemia.
References in periodicals archive ?
[28] proposed a hybrid differential evolution with transform function (HtDE) and proved its convergence.
[28] developed a convergent algorithm, HtDE and proved its convergence.
I stood in the insuck of hot air through the open front door and watched Aaron navigate his way up the crisscross redbrick walkway Massive cockroaches, illuminated in the front porch lights, flew across his path, causing him to skip and dodge and do a minstrel-like htde dance.
The intent of the designers was to use as htde foam as possible rather than drenching an individual, he said.