AKAP13

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AKAP13

A gene on chromosome 15q24-q25 that encodes a member of the structurally diverse A-kinase anchor protein (AKAP) family, which binds to the regulatory subunits (RI/RII) of cAMP-dependent protein kinase A (PKA), confining PKA to discrete locations within the cell based on different targeting motifs. Alternative splicing of AKAP13 results in at least 3 transcript variants that encode different isoforms containing a dbl oncogene homology (DH) domain and a pleckstrin homology (PH) domain with various functions. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP-binding proteins, activating GTPase and resulting in signal transduction. The isoforms function as scaffolding proteins to co-ordinate a Rho-signalling pathway and function as PKA-anchoring proteins
References in periodicals archive ?
miyamotoi strain HT31 (tick isolate, Japan) and Izh-16 (clinical isolate, Russia) compared with reactivity to the B.
miyamotoi strain HT31. Furthermore, we thank Alex Wagemakers, Tal Azagi, and Bob de Wever for their contributions to the manuscript.
miyamotoi strain HT31 was prepared as described (9) and was used as a quantitative control.
persulcatus ticks were almost indistinguishable from the corresponding sequences of the prototype Japan HT31 strain (1 ) (Figure 3).
miyamotoi strains HT24, HT31, and HK004 from L persulcalus ticks and strains NB103-1 and FR64b from Apodemus spp.