Some small heat shock proteins are tissue specific in human such as HspB2, HspB3, [alpha]-crystalline (HspB4), HspB7, HspB9, and HspB10, while others are expressed in all human tissues including HspBl, aB-crystalline (Hsp-B5), HspB6 (20 kDa) and HspB8 (10-17).