Some small heat shock proteins are tissue specific in human such as HspB2, HspB3, [alpha]-crystalline (HspB4), HspB7
, HspB9, and HspB10, while others are expressed in all human tissues including HspBl, aB-crystalline (Hsp-B5), HspB6 (20 kDa) and HspB8 (10-17).
Genetic association study identifies HSPB7
as a risk gene for idiopathic dilated cardiomyopathy.
Washington, Oct 22 (ANI): Researchers have identified a common variant of the cardiovascular heat shock protein gene, HSPB7, which was found to increase risk for dilated cardiomyopathy by almost 50pc.
The HSPB7 gene was strongly associated with susceptibility to DCM.
In a GWAS of dilated cardiomyopathy--an uncommon form of HF (1 in 2500 adults) with a risk of familial recurrence of approximately 30%--investigators discovered and replicated the results for 2 HF-associated loci near the HSPB7 [heat shock 27kDa protein family, member 7 (cardiovascular)] andBAG3 (BCL2-associated athanogene 3) genes, (6).
 Human genes: USP3, ubiquitin specific peptidase 3; HSPB7, heat shock 27kDa protein family, member 7 (cardiovascular); BAG3, BCL2-associated athanogene 3; APOE, apolipoprotein E; SORT1, sortilin 1.
Washington, Dec 15 (ANI): Researchers at Washington University School of Medicine, St Louis, have identified a group of 12 genetic variants in the HSPB7
gene, which is linked to heart failure in humans.