HSPB3

HSPB3

A gene on chromosome 5q11.2 that encodes a member of the (small) heat shock protein 20 family that inhibits actin polymerisation.

Molecular pathology
Defects of HSPB3 cause distal hereditary motor neuronopathy type 2C.
References in periodicals archive ?
Some small heat shock proteins are tissue specific in human such as HspB2, HspB3, [alpha]-crystalline (HspB4), HspB7, HspB9, and HspB10, while others are expressed in all human tissues including HspBl, aB-crystalline (Hsp-B5), HspB6 (20 kDa) and HspB8 (10-17).
Expression of early growth response 1 (EGR1), MMP1, synaptotagmin 7 (SYT7), inositol 1,4,5-trisphosphate 3kinase a (ITPKA), CCL2, neurotrimin (NTM), insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3), neuropilin 1 (NRP1), potassium channel tetramerization domain-containing protein 12 (KCTD12), heat-shock 27 kD protein 3 (HSPB3), transmembrane 4 L six family member 20 (TM4SF20), regulator of G protein signaling 4 (RGS4), NAMPT, COX2, and glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was detected by real-time PCR using the iCycler iQ detection system (Bio-Rad Laboratories), SYBR Green (Bio-Rad Laboratories), and specific primers (QuantiTect Primer Assay, Qiagen).
The 3 NAMPT-downregulated genes comprised HSPB3, TM4SF20, and RGS4 (Table 1).
Muscle develops a specific fprm of small heat shock protein complex composed of MKBP/HspB2 and HspB3 during myogenic differentiation.