HSPB1

HSPB1

A gene on chromosome 7q11.23 that encodes a member of the (small) heat shock protein 20 family which is induced by environmental stress. HSPB1 plays a role in stress resistance and actin organisation; it translocates from the cytoplasm to the nucleus in response to stress. It associates with alpha- and beta-tubulin, microtubules and CRYAB, and interacts with HSPB8 and HSPBAP1.

Molecular pathology
Defects of HSPB1 cause Charcot-Marie-Tooth disease type 2F and distal hereditary motor neuropathy 2B.
References in periodicals archive ?
Spot Accession number number Protein name M17 K22E Keratin, type II cytoskeletal 2 epidermal M18 Q6NTA2 HNRNPL protein M19 Q32Q12 Nucleoside diphosphate kinase M20 ALDOA Fructose-bisphosphate aldolase A M21 PEBP1 Phosphatidylethanolamine-binding protein 1 M22 PGAM1 Phosphoglycerate mutase 1 N13 GMFB Glia maturation factor beta N14 HSPB1 Heat shock protein beta-1 N15 TP1S Triosephosphate isomerase M23 PGAM1 Phosphoglycerate mutase 1 M24 ENOA Alpha-enolase Spot Theoretical Theoretical Number of number Gene name Mr pl peptide Score M17 KRT2 65,678.
HSPB1 was up regulated in LD and DP depots during myogenic differentiation, whereas TCP-1 was identified in ST depot and its protein expressions were up regulated.
The HSPB1 and TCP-1 are chaperone proteins that promote cell survival during physiological stress (Sternlicht et al.
Our image analysis along with in-depth spot analysis (lower panel of Figure 4A, B and C) revealed omental depot with higher expressions of ANXA 6, HSPB1, TAGLN, ALDH1A1 and CALD 1, whereas in the subcutaneous depot, expressions of PRDX 6 and GSN were found to be high.