HSPA8


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HSPA8

A gene on chromosome 11q24.1 that encodes a ubiquitous member of the heat shock protein 70 (HSP70) family which acts as a chaperone by binding to nascent polypeptides to facilitate correct folding. HSPA8 also acts as an ATPase in disassembling clathrin-coated vesicles during transport of membrane components through the cell. It also downregulates transcription of CITED and HSC70.
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Using FDR p < 0.05, six enriched pathways were identified including "Notch Signaling Pathway" (genes NOTCH4 and DVL2), "Rlio GTPase cycle" {FAM 13A; HMHA1; VAV2; and GMIP), "Neurotransmitter Release Cycle" (HSPA8; and RIMS1), and "GABA synthesis, release, reuptake and degradation" (HSPA8; and RIMS1).
Prenatal Particulate Air Pollution and DNA Methylation in Newborns: An Epigenome-Wide Meta-Analysis
(34) The report shows great similarities in the expression of genes associated with odontogenesis, such as Il10, Traf6, Lef1 and Hspa8, as well as differences in induction and repression of genes such as Jak2 and Fas, both associated with proliferation, differentiation and apoptosis, during the process of odontogenesis.
Effect of grape seed extract (GSE) on functional activity and mineralization of OD-21 and MDPC-23 cell lines
Only a subset of Hsp70 chaperones, namely, HSPA1A, HSPA1B, and HSPA6, show stress-induced expression patterns, whereas the other Hsp70 family members, such as HSPA8 (often referred to as Hsc70), are expressed constitutively at baseline conditions [20].
Chaperone-Based Therapies for Disease Modification in Parkinson's Disease
This includes a list of 7 well-connected proteins HYOU1, GANAB, CALR, HSPA5, HSP90B1, VCP, and HSPA8 as determined by PPI analysis (Figure 1(c)).
Resveratrol Modulation of Protein Expression in parkin-Mutant Human Skin Fibroblasts: A Proteomic Approach
Diurnally regulated UGP2, HSPA8, PPP2CB, DAZAP2, EIF4G2, et al.
Analyzing gene expression profiles in dilated cardiomyopathy via bioinformatics methods
As expected, proteins belonging to the same pathway (e.g., glycolysis) show overall good correlation (Figure S1.D, red CV% <35%), reflecting their regulated coexpression, but they also show quantitatively stable expression with other functional pathways: for example, the molar expression level of the Krebs cycle enzyme malate dehydrogenase 2 (MDH2) is relatively stable not only towards enzymes of the upstream glycolysis (ALDOA, TPI1, GAPDH, and PGK1), but also to the amount of downstream mitochondrial F0F1 ATPase (ATP5A1), and even to unrelated functional pathways such as proteins synthesis/turnover (ubiquitin C, UBC, and heat shock protein A8, HSPA8), cytoskeleton (profilin 1, PFN1), and cell signaling (calmodulin 1, CALM1).
Species-related differences in the proteome of rat and human pancreatic beta cells
The addition of heat shack protein HSPA8 to cryapratective media improves the survival of brawn bear (Ursus 2rotus) spermatozoa during chilling and after cryapreservatian.
Viability of the six-banded armadillos (Euphractus sexcinctus) semen centrifuged and extended in Tris or powdered coconut water/ Viabilidade do semen de tatus-peba (Euphractus sexcinctus) centrifugado e diluido em Tris ou agua de coco em po
Gazouli et al., "HSP90, HSPA8, HIF-1 a and HSP70-2 polymorphisms in breast cancer: a case-control study," Molecular Biology Reports, vol.
Heat shock protein 70 gene polymorphisms and cancer risk: a meta-analysis
TcHsp70B, an orthologue of Bos taurus HSPA8, was used as a positive control.
Investigating the chaperone properties of a novel heat shock protein, Hsp70.c, from Trypanosoma brucei
We have found that the HSPa8 gene coding protein, heat shock cognate protein 70 (HSC70) is expressed in both sensitive (L1210/0) and DDP-MTX cross resistant (L1210/DDP) leukemia cells.
Cloning of the HSPa8 gene from L1210 murine leukemia cells, expression and purification of the HSC70 protein in Escherichia coli cells using an affinity chromatography technique
The importance of HSPs in maintaining proteostasis within oocytes takes on added significance in light of evidence that oocytes obtained from aged mice exhibit a marked decrease in the gene expression of Hsp40s (Dnaja2, Dnaja4, Dnajb1, Dnajb6, Dnajb10, Dnajb11, Dnajc3, Dnajc5, Dnajc8, and Dnajc21), Hsp70s (Hspa1b, Hspa4, Hspa8, Hspa9a, Hspa14, and Hsp70-3), Hsp90s (Hspcb), and components of the chaperonin containing TCP1 complex (Cct1-3 and Cct5) (Table 1) [3, 97].
Molecular Mechanisms Responsible for Increased Vulnerability of the Ageing Oocyte to Oxidative Damage
It was not until 1990 that Liu and Maxwell described that the intronic sequences of the mouse hsc70 heat shock gene (HSPA8) were the source for U14 snoRNA [51].
Colorectal Cancer: From the Genetic Model to Posttranscriptional Regulation by Noncoding RNAs
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