HSPA8


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HSPA8

A gene on chromosome 11q24.1 that encodes a ubiquitous member of the heat shock protein 70 (HSP70) family which acts as a chaperone by binding to nascent polypeptides to facilitate correct folding. HSPA8 also acts as an ATPase in disassembling clathrin-coated vesicles during transport of membrane components through the cell. It also downregulates transcription of CITED and HSC70.
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Using FDR p < 0.05, six enriched pathways were identified including "Notch Signaling Pathway" (genes NOTCH4 and DVL2), "Rlio GTPase cycle" {FAM 13A; HMHA1; VAV2; and GMIP), "Neurotransmitter Release Cycle" (HSPA8; and RIMS1), and "GABA synthesis, release, reuptake and degradation" (HSPA8; and RIMS1).
(34) The report shows great similarities in the expression of genes associated with odontogenesis, such as Il10, Traf6, Lef1 and Hspa8, as well as differences in induction and repression of genes such as Jak2 and Fas, both associated with proliferation, differentiation and apoptosis, during the process of odontogenesis.
Only a subset of Hsp70 chaperones, namely, HSPA1A, HSPA1B, and HSPA6, show stress-induced expression patterns, whereas the other Hsp70 family members, such as HSPA8 (often referred to as Hsc70), are expressed constitutively at baseline conditions [20].
This includes a list of 7 well-connected proteins HYOU1, GANAB, CALR, HSPA5, HSP90B1, VCP, and HSPA8 as determined by PPI analysis (Figure 1(c)).
Diurnally regulated UGP2, HSPA8, PPP2CB, DAZAP2, EIF4G2, et al.
As expected, proteins belonging to the same pathway (e.g., glycolysis) show overall good correlation (Figure S1.D, red CV% <35%), reflecting their regulated coexpression, but they also show quantitatively stable expression with other functional pathways: for example, the molar expression level of the Krebs cycle enzyme malate dehydrogenase 2 (MDH2) is relatively stable not only towards enzymes of the upstream glycolysis (ALDOA, TPI1, GAPDH, and PGK1), but also to the amount of downstream mitochondrial F0F1 ATPase (ATP5A1), and even to unrelated functional pathways such as proteins synthesis/turnover (ubiquitin C, UBC, and heat shock protein A8, HSPA8), cytoskeleton (profilin 1, PFN1), and cell signaling (calmodulin 1, CALM1).
The addition of heat shack protein HSPA8 to cryapratective media improves the survival of brawn bear (Ursus 2rotus) spermatozoa during chilling and after cryapreservatian.
Gazouli et al., "HSP90, HSPA8, HIF-1 a and HSP70-2 polymorphisms in breast cancer: a case-control study," Molecular Biology Reports, vol.
TcHsp70B, an orthologue of Bos taurus HSPA8, was used as a positive control.
We have found that the HSPa8 gene coding protein, heat shock cognate protein 70 (HSC70) is expressed in both sensitive (L1210/0) and DDP-MTX cross resistant (L1210/DDP) leukemia cells.
The importance of HSPs in maintaining proteostasis within oocytes takes on added significance in light of evidence that oocytes obtained from aged mice exhibit a marked decrease in the gene expression of Hsp40s (Dnaja2, Dnaja4, Dnajb1, Dnajb6, Dnajb10, Dnajb11, Dnajc3, Dnajc5, Dnajc8, and Dnajc21), Hsp70s (Hspa1b, Hspa4, Hspa8, Hspa9a, Hspa14, and Hsp70-3), Hsp90s (Hspcb), and components of the chaperonin containing TCP1 complex (Cct1-3 and Cct5) (Table 1) [3, 97].
It was not until 1990 that Liu and Maxwell described that the intronic sequences of the mouse hsc70 heat shock gene (HSPA8) were the source for U14 snoRNA [51].